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SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE

SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
选择性去除眼外肌
批准号：
2888620
负责人：
ALAN B SCOTT
金额：
$19.73万
依托单位：
SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 2001-07-31
来源：
https://reporter.nih.gov/project-details/2888620
关键词：
Primates denervation extraocular muscle eye coordination disorder eye laser surgery eye movements eye surgery laboratory rabbit microsurgery muscle function nonhuman therapy evaluation postoperative state saccades smooth pursuit eye movement technology /technique development

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中文摘要
翻译
目的1定义人眼外显微外科解剖
英文摘要
DESCRIPTION: Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development. Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle. Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle. Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated. Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.
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