CHEMICAL ALTERATION OF EXTRAOCULAR MUSCLE FUNCTION

我们将进行一项临床试验， 眼外肌作为成人和儿童斜视的治疗方法 提供最佳剂量、有效时间和安全性数据 在成人和儿童。 我们将尝试记录下 通过CAT扫描，物理测量， 肌肉长度和张力数据，并通过组织学的眼外肌。 我们将评估注射在其他条件下的效果，包括 眼睑痉挛，眼球震颤，睑内翻，眼睑退缩。 我们将探讨 其他药物对眼外肌功能的影响，特别是 肉毒杆菌毒素-D、石房蛤毒素和α银环蛇毒素。 我们将比较 这种药物注射技术的有效性，一旦最佳剂量 时间表是确定的，手术技术的结果， 矫正斜视的眼睛

We will conduct a clinical trial of the effort of botulinum-A toxin on extraocular muscle as a therapy for strabismus in adults and children in order to provide data on optimum dose, length of effectiveness, and safety in adults and children. We will attempt to document the physical mechanism by which eye muscle function is changed through CAT scan, physical measure of muscle length and tension data, and by histology of extraocular muscle. We will assess the effect of injection in other conditions including blepharospasm, nystagmus, entropion, lid retraction. We will explore the effect of other drugs on extraocular muscle function, particularly botulinum toxin-D, saxitoxin, and alpha bungarotoxin. We shall compare the effectiveness of this drug injection technique, once optimum dosage schedules are determined, with the results of surgical techniques to realign the eye in strabismus.