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SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE

SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
选择性去除眼外肌
批准号：
6179029
负责人：
ALAN B SCOTT
金额：
$19.5万
依托单位：
SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-08-01 至 2003-11-30
来源：
https://reporter.nih.gov/project-details/6179029
关键词：
Primates denervation extraocular muscle eye coordination disorder eye laser surgery eye movements eye surgery laboratory rabbit microsurgery muscle function nonhuman therapy evaluation postoperative state saccades smooth pursuit eye movement technology /technique development

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中文摘要
翻译
描述：Aim 1定义了人类眼外的显微外科解剖 这是发展铒激光程序所需的肌肉。目标2 代表了适应商业Er的设计/开发阶段 用于选择性弱化眼外肌的激光。目标 3和4使用兔子模型来开发特定于 靶向切除纵行肌条和失神经支配 选定的眼外肌节段。目标5适用于目标 在兔身上发展成次人灵长类的肌肉折衷程序 肌肉形态和定量眼动的模型 行为可能是紧密相关的。目标6代表人体试验研究 用于设计在此开发的疗法的临床试验所需的 求婚。
英文摘要
DESCRIPTION: Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development. Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle. Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle. Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated. Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.
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