SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE

选择性去除眼外肌

• 批准号: 6179029
• 负责人: ALAN B SCOTT
• 金额: $ 19.5万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6179029
• 关键词: Primates; denervation; extraocular muscle; eye coordination disorder; eye laser surgery; eye movements; eye surgery; laboratory rabbit; microsurgery; muscle function; nonhuman therapy evaluation; postoperative state; saccades; smooth pursuit eye movement; technology /technique development

DESCRIPTION: Aim 1 defines the microsurgical anatomy of human extraocular muscle that is needed for erbium laser procedure development. Aim 2 represents a design/development phase in adapting a commercial erbium laser for the purpose of selective weakening of extraocular muscle. Aims 3 and 4 use a rabbit model to develop laser applications specific for the targeted removal of a longitudinal muscle strip and denervation of selected segments of extraocular muscle. Aim 5 applies the targeted muscle compromise procedures developed in the rabbit to a subhuman primate model in which both muscle morphology and quantitative eye movement behavior can be tightly correlated. Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal.

描述：目的1定义了人类眼外的显微外科解剖结构 铒激光程序开发所需的肌肉。 目的2 代表了适应商业铒的设计/开发阶段 激光用于选择性减弱眼外肌。 旨在 图3和图4使用兔子模型来开发特定于 有针对性地去除纵向肌肉条和去神经支配， 眼外肌的特定部分。 目标5适用于目标 肌肉妥协程序开发的兔子到一个亚人灵长类动物 模型中，肌肉形态和定量眼球运动 行为是紧密相关的。 Aim 6代表人类试点研究 需要设计的临床试验的治疗开发， 提议