RICIN REDUCTION OF MUSCLE FUNCTION
RICIN REDUCTION OF MUSCLE FUNCTION
批准号:
3265532
负责人:
ALAN B SCOTT
金额:
$15.02万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-08-01 至 1993-07-31
关键词:
blood chemistry central nervous system disorders dosage drug administration routes drug adverse effect electromyography electron microscopy extraocular muscle eye movements eyelids heart function histology injection /infusion kidney function laboratory rabbit liver function microscopy muscle function muscle pharmacology neuronal transport
中文摘要
该项目旨在确定剂量和注射方法,
蓖麻毒素,这将永久减少眼睑和眼旋转肌
在家兔中发挥作用,无过度的局部或全身不良反应
方面的影响. 减少肌肉大小,肌肉再生和其他
对目标肌肉的影响将通过功能测试和
光学和电子显微镜。 对邻近组织的影响
通过临床检查和组织学评估。 神经元的作用
将通过以下方法评估向中枢神经系统和在中枢神经系统内的转运:
组织学 将通过肝、肾、
和心脏功能以及这些器官的组织学。 如果这些
实验是成功的,这种方法和这些数据将形成
局灶性肌张力障碍的实验性临床药物治疗的基础。
英文摘要
This project seeks to determine the dose and the method of injection of
ricin, which will permanently reduce eyelid and oculo-rotary muscle
function in the rabbit without excessive adverse local or systemic side
effects. Reduction in muscle size, muscle regeneration, and other
effects on the target muscle will be assessed by functional tests and by
light and electronmicroscopy. Effect on adjacent tissues will be
assessed by clinical examination and by histology. Effects of neuron
transport to and within the central nervous system will be assessed by
histology. Systemic effects will be monitored by tests of liver, renal
and cardiac function and by histology of these organs. If these
experiments are successful, this approach and these data will form the
basis of an experimental, clinical drug treatment for focal dystonias.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Preventing ptosis after botulinum treatment.
肉毒杆菌治疗后预防上睑下垂。
DOI:
10.1097/00002341-199706000-00002
发表时间:
1997
期刊:
Ophthalmic plastic and reconstructive surgery
影响因子:
2
作者:
[Scott,AB]
通讯作者:
Scott,AB
Extraocular Muscle (EOM) Responses to Bupivacaine Injection
-
批准号:8327823
-
项目类别:
-
资助金额:$60.66万
-
财政年份:2009
-
负责人:ALAN B SCOTT
-
依托单位:
SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
-
批准号:6179029
-
项目类别:
-
资助金额:$19.5万
-
财政年份:1998
-
负责人:ALAN B SCOTT
-
依托单位:
SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
-
批准号:6555187
-
项目类别:
-
资助金额:$10.63万
-
财政年份:1998
-
负责人:ALAN B SCOTT
-
依托单位:
SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
-
批准号:2888620
-
项目类别:
-
资助金额:$19.73万
-
财政年份:1998
-
负责人:ALAN B SCOTT
-
依托单位:
SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
-
批准号:2669595
-
项目类别:
-
资助金额:$25.33万
-
财政年份:1998
-
负责人:ALAN B SCOTT
-
依托单位:
SMALL INSTRUMENTATION GRANT
-
批准号:3524477
-
项目类别:
-
资助金额:$1.61万
-
财政年份:1990
-
负责人:ALAN B SCOTT
-
依托单位:
DYSTONIA TREATMENT BY BOTULINUM TOXINS
-
批准号:3265587
-
项目类别:
-
资助金额:$10.99万
-
财政年份:1989
-
负责人:ALAN B SCOTT
-
依托单位:
RICIN REDUCTION OF MUSCLE FUNCTION
-
批准号:3265530
-
项目类别:
-
资助金额:$16.04万
-
财政年份:1989
-
负责人:ALAN B SCOTT
-
依托单位:
RICIN REDUCTION OF MUSCLE FUNCTION
-
批准号:3265531
-
项目类别:
-
资助金额:$13.85万
-
财政年份:1989
-
负责人:ALAN B SCOTT
-
依托单位:
DYSTONIA TREATMENT BY BOTULINUM TOXINS
-
批准号:3265589
-
项目类别:
-
资助金额:$11.87万
-
财政年份:1989
-
负责人:ALAN B SCOTT
-
依托单位:
DYSTONIA TREATMENT BY BOTULINUM TOXINS
-
批准号:3265588
-
项目类别:
-
资助金额:$11.49万
-
财政年份:1989
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517472
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517471
-
项目类别:
-
资助金额:$1.95万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517467
-
项目类别:
-
资助金额:$5.64万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517468
-
项目类别:
-
资助金额:$5.82万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517470
-
项目类别:
-
资助金额:$4.24万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
BIOMEDICAL RESEARCH SUPPORT GRANT
-
批准号:3517469
-
项目类别:
-
资助金额:$5.38万
-
财政年份:1987
-
负责人:ALAN B SCOTT
-
依托单位:
CHEMICAL ALTERATION OF EXTRAOCULAR MUSCLE FUNCTION
-
批准号:3262815
-
项目类别:
-
资助金额:$23.31万
-
财政年份:1985
-
负责人:ALAN B SCOTT
-
依托单位:
CHEMICAL ALTERATION OF EXTRAOCULAR MUSCLE FUNCTION
-
批准号:3262817
-
项目类别:
-
资助金额:$21.08万
-
财政年份:1985
-
负责人:ALAN B SCOTT
-
依托单位:
CHEMICAL ALTERATION OF EXTRAOCULAR MUSCLE FUNCTION
-
批准号:3262818
-
项目类别:
-
资助金额:$8.0万
-
财政年份:1985
-
负责人:ALAN B SCOTT
-
依托单位:
海外基金