FUNCTION OF ASCORBATE PEROXIDASE IN THE EYE
FUNCTION OF ASCORBATE PEROXIDASE IN THE EYE
批准号:
3265422
负责人:
KWOK-WAI LAM
金额:
$7.12万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-09-01 至 1993-08-31
中文摘要
细胞氧化反应中产生的自由基的毒性是
英文摘要
The toxicity of free radicals produced in cellular oxidative reactions is
well known. In eye tissues, the frequent exposure to light poses an
additional source of free radical. Peroxidase is the major enzyme system i
the retinal pigment epithelium to prevent accumulation of H2O2. The detail
d
biochemical nature of this enzyme in the retinal pigment epithelium and its
identity of the peroxidase of other tissues is not known. The present
specific aim is to purify the major peroxidase from the retinal pigment
epithelium, compare its properties with that of erythrocytes, granulocytes,
and to produce a specific antibody for the purified peroxidase. The antibo
y
will be used to visualize its location in the eye tissues.
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Kinetic properties of light-dependent ascorbic acid oxidation by melanin.
黑色素光依赖性抗坏血酸氧化的动力学特性。
DOI:
10.1016/0891-5849(93)90045-v
发表时间:
1993
期刊:
Free radical biology & medicine
影响因子:
7.4
作者:
[Glickman,RD, Sowell,R, Lam,KW]
通讯作者:
Lam,KW
Comparison of ascorbic acid levels in the eye and remainder of the chicken embryo during development.
比较发育过程中眼睛和鸡胚其余部分的抗坏血酸水平。
DOI:
10.1016/0014-4835(92)90053-u
发表时间:
1992
期刊:
Experimental eye research
影响因子:
3.4
作者:
[Zwaan,J, Lam,KW]
通讯作者:
Lam,KW
Sodium-dependent ascorbic and dehydroascorbic acid uptake by SV-40-transformed retinal pigment epithelial cells.
SV-40 转化的视网膜色素上皮细胞对钠依赖性抗坏血酸和脱氢抗坏血酸的摄取。
DOI:
10.1159/000267272
发表时间:
1993
期刊:
Ophthalmic research
影响因子:
2.1
作者:
[Lam,KW, Yu,HS, Glickman,RD, Lin,T]
通讯作者:
Lin,T
Comparison of peroxidases in the retina, choroid and red blood cells.
视网膜、脉络膜和红细胞中过氧化物酶的比较。
DOI:
10.1159/000267476
发表时间:
1994
期刊:
Ophthalmic research
影响因子:
2.1
作者:
[Wang,L, Lam,KW, Lam,TT, Glickman,RD]
通讯作者:
Glickman,RD
Correlation of phospholipid hydroperoxide glutathione peroxidase activity to the sensitivity of rat retinas to photic injury.
磷脂氢过氧化物谷胱甘肽过氧化物酶活性与大鼠视网膜对光损伤敏感性的相关性。
DOI:
10.1159/000267376
发表时间:
1994
期刊:
Ophthalmic research
影响因子:
2.1
作者:
[Wang,L, Lam,TT, Lam,KW, Tso,MO]
通讯作者:
Tso,MO
共 8 条
FUNCTION OF ASCORBATE PEROXIDASE IN THE EYE
-
批准号:3265420
-
项目类别:
-
资助金额:$6.75万
-
财政年份:1989
-
负责人:KWOK-WAI LAM
-
依托单位:
FUNCTION OF ASCORBATE PEROXIDASE IN THE EYE
-
批准号:3265421
-
项目类别:
-
资助金额:$6.72万
-
财政年份:1989
-
负责人:KWOK-WAI LAM
-
依托单位:
IMMUNOCYTOCHEMISTRY OF PROSTATIC ACID PHOSPHATASE
-
批准号:3174607
-
项目类别:
-
资助金额:$8.27万
-
财政年份:1984
-
负责人:KWOK-WAI LAM
-
依托单位:
IMMUNOCYTOCHEMISTRY OF PROSTATIC ACID PHOSPHATASE
-
批准号:3174608
-
项目类别:
-
资助金额:$8.13万
-
财政年份:1984
-
负责人:KWOK-WAI LAM
-
依托单位:
BIOCHEM AND CLINICAL APPLICATION OF ACID PHOSPHATASE 5
-
批准号:3172700
-
项目类别:
-
资助金额:$10.29万
-
财政年份:1982
-
负责人:KWOK-WAI LAM
-
依托单位:
BIOCHEM AND CLINICAL APPLICATION OF ACID PHOSPHATASE 5
-
批准号:3172702
-
项目类别:
-
资助金额:$9.34万
-
财政年份:1982
-
负责人:KWOK-WAI LAM
-
依托单位:
BIOCHEM AND CLINICAL APPLICATION OF ACID PHOSPHATASE 5
-
批准号:3172703
-
项目类别:
-
资助金额:$11.14万
-
财政年份:1982
-
负责人:KWOK-WAI LAM
-
依托单位:
海外基金