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Understanding, forecasting, and mitigating zoonotic mosquito-borne viral disease in the U.K.

了解、预测和减轻英国人畜共患蚊媒病毒性疾病

基本信息

批准号：
BB/X018024/1
负责人：
Grant Leslie Hughes
金额：
$ 129.47万
依托单位：
Liverpool School of Tropical Medicine
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FX018024%2F1
关键词：
Understanding forecasting mitigating zoonotic mosquito

项目摘要

Effective surveillance and control of vector-borne disease (VBD) in the UK requires an integrative approach. This multi-disciplinary project combines diverse expertise from medical entomology, virology to computational modelling to investigate areas related to the understanding, forecasting, and mitigation of mosquito-borne disease in the UK. By forging partnerships across several institutions, we will address questions including (i) how and where local transmission will most likely occur; (ii) how can proven vector control strategies be adapted to a UK context; and (iii) and investigate novel approaches to mitigate risk. Our collaboration spans academic, industry, and governmental organisations, providing the unique capacity and expertise needed to address these questions. The first work package (WP) (led by Co-I Dr Jones and Co-I Dr Lord [Early Career Researcher - ECR]) will determine factors that influence the potential for transmission of WNV over a fine scale using field studies and computational modelling. This includes mosquito community composition in different habitats, movement between these habitats (Dr Chapman), and whether mosquito and bird communities have the capacity to sustain transmission (Dr Mason, STFC Hartree). Models of WNV transmission will then be used to determine the efficacy of control strategies in the context of these communities. Focusing on these fine-scale dynamics is important as this granularity may be overlooked in broad scale national surveys, and the questions raised here will inform on the usefulness and reliability of these surveys. In work package two (led by RCo-I Dr Longbottom [ECR] and Co-I Dr Lord [ECR]), we will produce species distribution maps for potential WNV vectors. Previous estimates are over 10 years old and additional contemporary spatial data has since become available. Additionally, this work package will explore different spatial scales for model prediction and accuracy and investigate the use of outputs of varying scales in policy and implementation. Elements of this work package will leverage partnerships at UKHSA to facilitate stakeholder discussion and research uptake. Collectively WP1 and 2 will build on existing WNV risk assessments to inform government policy, by providing fine-scale data and a focus on communities of mosquitoes rather than individual species. In the final work package, we will explore novel and proven vector control strategies for their applicability to the UK. In part A (led by PI Dr Hughes), we will partner with Verily Life Sciences and Dr Walker (University of Warwick) to develop a Wolbachia-based control strategy for Culex mosquitoes. We will introgress a novel Wolbachia strain into the Culex molestus background and examine its capacity to alter mosquito reproduction and suppress mosquito populations. Additionally, we will examine the ability of Wolbachia to block pathogens relevant to the UK including WNV and Usutu virus (USUV). Results from this work will form the basis of future control approaches and our partnership with Verily Life Sciences uniquely places us to rapidly transition this research into an applied control approach in the UK. In part B of this final work package (led by RCo-I Dr Casas-Sanchez), we will examine how glycosylation pathways affect arboviruses such as WNV and USUV in vitro and in vivo. The ability to block the virus, rather than target the mosquito enables vector control approaches that can work across mosquito species, a critical factor given the role of multi-species communities in transmission (identified in WP1). We have ECRs as work packages leads and we commit to mentoring these researchers in this project and more generally towards their independence. Together, our OneHealth approach and spectrum of understanding, forecasting, and mitigation of VBD will provide critical data for future planning and research as we move towards the aim of reducing the risk of transmission in the UK.

在英国，有效监测和控制病媒传播疾病（VBD）需要采取综合方法。这个多学科项目结合了从医学昆虫学，病毒学到计算建模的各种专业知识，以调查与英国蚊媒疾病的理解，预测和缓解相关的领域。通过在多个机构建立伙伴关系，我们将解决以下问题：（i）如何以及在何处最有可能发生本地传播;（ii）如何将经验证的病媒控制策略适用于英国环境;以及（iii）研究降低风险的新方法。我们的合作涵盖学术，工业和政府组织，提供解决这些问题所需的独特能力和专业知识。第一个工作包（WP）（由Co-I Jones博士和Co-I Lord博士[早期职业研究员- ECR]领导）将使用实地研究和计算建模来确定影响WNV传播潜力的因素。这包括不同栖息地的蚊子群落组成，这些栖息地之间的移动（查普曼博士），以及蚊子和鸟类群落是否有能力维持传播（梅森博士，STFC Hartree）。西尼罗河病毒的传播模型，然后将被用来确定在这些社区的背景下，控制策略的有效性。关注这些细尺度动态是重要的，因为这种粒度可能会被忽视，在大规模的国家调查，这里提出的问题将告知这些调查的有用性和可靠性。在第二个工作包（由RCo-I Longbottom博士[ECR]和Co-I Lord博士[ECR]领导）中，我们将为潜在的WNV载体绘制物种分布图。以前的估计是10多年前的，后来又有了更多的当代空间数据。此外，该工作包将探讨不同的空间尺度，以实现模型预测和准确性，并调查不同尺度的产出在政策和执行中的使用情况。该工作包的要素将利用UKHSA的伙伴关系，以促进利益相关者的讨论和研究吸收。WP 1和WP 2将共同建立在现有的西尼罗河病毒风险评估的基础上，通过提供精细的数据和重点关注蚊子群落而不是单个物种，为政府政策提供信息。在最后的工作包中，我们将探索新的和经过验证的矢量控制策略，其适用于英国。在A部分（由PI Hughes博士领导）中，我们将与Verily Life Sciences和步行者博士（沃里克大学）合作，开发一种基于沃尔巴克氏体的库蚊控制策略。我们将一种新的沃尔巴克氏体菌株渗入到骚扰库蚊背景中，并研究其改变蚊子繁殖和抑制蚊子种群的能力。此外，我们将研究沃尔巴克氏体阻止与英国相关的病原体的能力，包括西尼罗河病毒和西尼罗河病毒（USUV）。这项工作的结果将成为未来控制方法的基础，我们与Verily Life Sciences的合作使我们能够将这项研究迅速转变为英国的应用控制方法。在这个最终工作包的B部分（由RCo-I Casas-Sanchez博士领导），我们将研究糖基化途径如何影响虫媒病毒，如WNV和USUV在体外和体内。阻断病毒而不是针对蚊子的能力使病媒控制方法能够在蚊子物种之间发挥作用，这是一个关键因素，因为多物种群落在传播中发挥作用（在WP 1中确定）。我们有ECR作为工作包的领导者，我们承诺在这个项目中指导这些研究人员，更广泛地说，是为了他们的独立。总之，我们的OneHealth方法和VBD的理解，预测和缓解范围将为未来的规划和研究提供关键数据，因为我们朝着降低英国传播风险的目标迈进。