Software-controlled assembly of oligomers

软件控制的低聚物组装

• 批准号: EP/F009062/2
• 负责人: Rachel O'Reilly
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF009062%2F2
• 关键词: Software; controlled; assembly; oligomers

We propose to create a molecular machine that will build new materials under software control. The output of the machine will be chains of building blocks linked by covalent bonds. The machine is modular and is designed to accept many different building blocks, from small molecules to nanoparticles, with a wide range of physical and chemical properties. In order to drive its development we will concentrate on using it to create two target products: a molecular wire, capable of transporting energy and electrical charge, and a catalyst. Software control starts with specification by the end-user of a sequence of building blocks. The target sequence is encoded in an instruction tape which can be read by the machine: the tape is itself a molecule, a synthetic DNA oligomer. The target sequence of building blocks is automatically converted into a control sequence of DNA bases, and the tape is produced by commercial solid-phase synthesis. The job of the machine is to read the instruction tape and to form the bonds between building blocks in the specified sequence. Every component of this molecular factory is itself a molecule: our ambition is to develop the system to the point where it could be distributed to end users as chemicals in plastic vials.

我们建议创造一种分子机器，在软件控制下制造新材料。机器的输出将是由共价键连接的积木链。该机器是模块化的，旨在接受许多不同的构建块，从小分子到纳米颗粒，具有广泛的物理和化学性质。为了推动它的发展，我们将集中精力用它来创造两个目标产品：一个分子线，能够传输能量和电荷，和一个催化剂。软件控制始于最终用户对一系列构建块的规范。目标序列被编码在一个指令带中，它可以被机器读取：这个指令带本身就是一个分子，一个合成的DNA寡聚体。结构单元的靶序列被自动转化为DNA碱基的控制序列，并且通过商业固相合成来生产条带。机器的工作是读取指令带，并按照指定的顺序在积木之间形成键。这个分子工厂的每一个组成部分本身就是一个分子：我们的目标是将该系统发展到可以作为塑料小瓶中的化学品分发给最终用户的程度。

项目成果

The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery.

• DOI: 10.1021/acs.accounts.7b00280
• 发表时间: 2017-10-17
• 期刊: Accounts of chemical research
• 影响因子: 18.3
• 作者: O'Reilly RK;Turberfield AJ;Wilks TR
• 通讯作者: Wilks TR