EPIDEMIOLOGY OF PREMATURE RUPTURE OF AMNIOTIC MEMBRANES

羊膜过早破裂的流行病学

• 批准号: 3318373
• 负责人: EDEM E EKWO
• 金额: $ 18.95万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3318373
• 关键词: age at pregnancy; amnion; amniotic fluid; case history; epidemiology; family sizes; female reproductive system surgery; fertility; gestational age; human pregnant subject; human subject; interview; pregnancy disorder; pregnancy loss; premature infant human; racial /ethnic difference; sex behavior; tobacco abuse

Premature rupture of amniotic sac membranes (PROM) increases risks of complication to both mother and infant. It increases the risk of premature birth particularly when it occurs at or before the 36th week of gestation. The purposes of the proposal is to study the epidemiologic factors associated with PROM. A matched case-control method will be used. Consenting mothers will be classified by pregnancy outcome into three groups: women with PROM occuring at (i) at less than 36 weeks gestation, (ii) at greater than 37 weeks of gestation, and (iii) women giving birth witout PROM to premature infants gestation less than 36 weeks). Each woman in the three groups will be singly matched by age, race, and parity to mothers of infants born vaginally or by C-section at term at greater than 39 weeks of gestation. Women will be interviewed within 72 hours of live delivery or within 14 +/- 2 days of delivery in case of death or seriously ill infants, by a trained interviewer. Data to be collected will include sociodemographic data, cigarette smoking data, gynecologic data including complications of previous and index pregnancy, and data about sexual activity before and during pregnancy. The data will be analyzed to show which factors are associated with increased risk of PROM occurring.

羊膜囊膜（PROM）的过早破裂会增加 母亲和婴儿的并发症。 它会增加早产的风险 分娩，特别是在妊娠第36周或之前。 该提案的目的是研究流行病学因素 与PROM有关。 将使用匹配的病例对照方法。 准妈妈们将根据怀孕结果分为三种 组：胎膜早破妇女发生在（i）妊娠小于36周， (ii)妊娠超过37周，以及（iii）分娩的妇女 无胎膜早破的早产儿妊娠期少于36周）。 每个女人 在这三个组中，将按年龄、种族和产次单独匹配， 足月时阴道分娩或剖腹产婴儿的母亲， 怀孕39周。 女性将在72小时内接受采访 分娩或在分娩后14 +/- 2天内死亡或严重 生病的婴儿，由训练有素的面试官。 收集的数据将包括 社会人口学数据、吸烟数据、妇科数据，包括 以前和指数妊娠的并发症，以及关于性行为的数据 怀孕前和怀孕期间的活动。 这些数据将被分析， 哪些因素与胎膜早破发生的风险增加有关。