METABOLISM IN THE NONHUMAN PRIMATE AND OVINE FETUS

非人灵长类动物和绵羊胎儿的新陈代谢

• 批准号: 3322806
• 负责人: Lynne L. Levitsky
• 金额: $ 23.73万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3322806
• 关键词: Cercopithecidae; biological models; carbohydrate biosynthesis; catecholamines; catheterization; embryo /fetus; endorphins; gestational diabetes mellitus; gluconeogenesis; glycogenolysis; high performance liquid chromatography; homeostasis; hormone regulation /control mechanism; kidney metabolism; liver metabolism; metabolism; placental transfer; prenatal stress; radioimmunoassay; radiotracer; sheep; tritium; ultrasound blood flow measurement

The study continues investigations into the nature of energy metabolism in the fetus. A chronic fetal lamb preparation and a chronic nonhuman primate model, the fetal baboon, are being used to extend previous studies of quantitative energy metabolism. Substrate uptake and production by the fetal animals is being evaluated by utilizing appropriately placed arterial and venous catheters for sampling arteriovenous metabolic differences, radioactive precursor tracer techniques, and measures of fetal blood flow and specific organ blood flows. We plan to study the capacity of the fetus to control gluconeogenesis, glycogenesis, and glycogenolysis in the face of a hostile maternal metabolic milieu, focusing particularly on endogenous hormonal or substrate mediated control mechanisms. In addition, pharmacologic probes of hormonal control mechanisms will be employed during steady state conditions in the pregnant animal. These studies are immediately relevant to the clinical problems of the infant of the diabetic mother, who may be exposed to acute hypoglycemia, or acute and chronic hyperglycemia, and to the infant of the calorically deprived, undernourished mother.

该研究继续调查能量代谢的本质