Alkenes as Nucleophiles in Catalytic Asymmetric C-C Bond Formation

烯烃作为催化不对称 C-C 键形成中的亲核试剂

• 批准号: EP/H003711/1
• 负责人: Stephen Fletcher
• 金额: $ 122.82万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FH003711%2F1
• 关键词: Alkenes; Nucleophiles; Catalytic; Asymmetric; Bond

This program aims to develop methods to use simple, readily available starting materials to build up more complex organic chemicals. The chemicals we are aiming to make have the property of being 'one handed' (for example, left handed), where the normal course of events in chemistry is to produce a 50:50 mixture of right and left handed molecules. Methods to produce one handed molecules already exist but are often impractical because they rely on using starting materials that contain metals (highly reactive and sensitive to temperature, air and water). Being able to use alkenes, which are readily available, rather than metal containing chemicals would simplify a number of very useful processes in chemistry and industry. This will allow certain valuable reactions to be done much more quickly and efficiently while minimizing waste and improve the process in a very 'green' way.

该计划旨在开发使用简单、容易获得的起始材料来建立更复杂的有机化学品的方法。我们的目标是制造的化学物质具有“单手”的性质(例如，左手)，在化学中，正常的过程是产生50：50的右手和左手分子的混合物。生产单手分子的方法已经存在，但往往不切实际，因为它们依赖于使用含有金属(高度活性和对温度、空气和水敏感)的起始材料。如果能够使用容易获得的烯烃，而不是含有金属的化学品，将简化化学和工业中许多非常有用的过程。这将使某些有价值的反应更快、更有效地完成，同时最大限度地减少浪费，并以非常“绿色”的方式改进过程。

项目成果

Simple Azo Dyes Provide Access to Versatile Chiroptical Switches

简单的偶氮染料提供了多功能手性光学开关

• DOI: 10.1002/ejoc.201500485
• 发表时间: 2015
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Anger E

Systems chemistry: Selecting complex behaviour.

系统化学：选择复杂的行为。

• DOI: 10.1038/nchem.2130
• 发表时间: 2015
• 期刊: Nature chemistry
• 影响因子: 21.8
• 作者: Bissette AJ

Novel applications of physical autocatalysis.

物理自催化的新应用。

• DOI: 10.1007/s11084-015-9404-y
• 发表时间: 2015
• 期刊: the journal of the International Society for the Study of the Origin of Life
• 作者: Bissette AJ

Enantioselective Conjugate Addition Catalyzed by a Copper Phosphoramidite Complex: Computational and Experimental Exploration of Asymmetric Induction

• DOI: 10.1021/acscatal.7b01453
• 发表时间: 2017-10-01
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Ardkhean, Ruchuta;Roth, Philippe M. C.;Fletcher, Stephen P.
• 通讯作者: Fletcher, Stephen P.