Alkenes as Nucleophiles in Catalytic Asymmetric C-C Bond Formation

该计划旨在开发方法，使用简单，现成的起始材料，以建立更复杂的有机化学品。我们要制造的化学物质具有“单手性”（例如，左手性）的性质，而化学中正常的过程是产生右手和左手分子50:50的混合物。制造单手分子的方法已经存在，但往往不切实际，因为它们依赖于使用含有金属的起始材料（金属对温度、空气和水具有高度反应性和敏感性）。能够使用容易获得的烯烃而不是含金属的化学物质，将简化化学和工业中许多非常有用的过程。这将使某些有价值的反应更快、更有效地完成，同时最大限度地减少浪费，并以一种非常“绿色”的方式改进过程。

This program aims to develop methods to use simple, readily available starting materials to build up more complex organic chemicals. The chemicals we are aiming to make have the property of being 'one handed' (for example, left handed), where the normal course of events in chemistry is to produce a 50:50 mixture of right and left handed molecules. Methods to produce one handed molecules already exist but are often impractical because they rely on using starting materials that contain metals (highly reactive and sensitive to temperature, air and water). Being able to use alkenes, which are readily available, rather than metal containing chemicals would simplify a number of very useful processes in chemistry and industry. This will allow certain valuable reactions to be done much more quickly and efficiently while minimizing waste and improve the process in a very 'green' way.