MORTALITY SURVEILLANCE OF MRFIT SCREENEES

MRFIT 筛查的死亡率监测

• 批准号: 3340023
• 负责人: MARCUS O KJELSBERG
• 金额: $ 15.69万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-04-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3340023
• 关键词: African American; blood chemistry; blood lipid; cancer risk; cardiovascular disorder epidemiology; caucasian American; cerebrovascular disorders; cholesterol; coronary disorder; disease /disorder proneness /risk; gastrointestinal neoplasms; human middle age (35-64); human mortality; hypertension; longitudinal human study; male; socioeconomics; tobacco abuse

This is a proposal to use the National Death Index to determine the 10 year mortality status of the 361,662 middle-aged men screened in 1973-75 for the Multiple Risk Factor Intervention Trial, to complete a number of analyses on the relationship of diastolic blood pressure, serum cholesterol and cigarette smoking with death from cardiovascular disease and cancer, and to initiate new analyses on the seasonal variation of cardiovascular risk factors and endpoints. Over 17,000 deaths have been identified in this cohort to date using data from the Social Security Administration; death certificates have been collected and coded for approximately 14,000 of these deaths. We estimate that using only the SSA for vital status ascertainment, we will miss 25% of the deaths occurring in calender years 1982-85, a period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up from 1974 the death ascertainment rate is estimated to be 80% if SSA is used. Our analyses with the 12,866 MRFIT randomized participants indicate that a 98% ascertainment rate would be achieved using the National Death Index for this critical time period, and the overall death ascertainment rate from 1974 to 1985 would be increased to 95%. With the complete 10 year follow-up of this large group of men analyses on risk factors from stroke and site specific cancer will be completed. In addition, this data set will be used to study the risks associated with isolated systolic hypertension, the seasonal and geographic variation in levels of serum cholesterol and blood pressure and the cyclic nature of cardiovascular disease. Using data from the Census Bureau (education and income levels by zip code), the socio-economic status of participants will be indirectly estimated and the coronary heart disease and cancer death rate difference between white and black men will be evaluated by social class. This data set on risk factors and mortality outcome is unique with respect to size and to the high level of quality control imposed during data collection. These aspects make the data particularly valuable for long-term follow-up and analysis.

这是一项使用国家死亡指数来确定 361，662名中年男性的10年死亡状况 在1973-75年进行多风险因素干预筛查 试验中，完成了一些关于 舒张压、血清胆固醇和吸烟 死于心血管疾病和癌症， 对心血管疾病的季节性变化进行新的分析 风险因素和终点。 迄今为止，在这一队列中已确定了17，000多例死亡 使用社会保障局的数据;死亡 证书已收集并编码约 其中14,000人死亡。 我们估计，仅使用SSA 我们会漏掉25%的死亡病例 发生在1982年至1985年的10年， 死亡率随着年龄的增长而增加。 在整个随访期间，死亡率 由于年龄的增长， 在整个 从1974年开始随访，估计死亡确定率 如果使用SSA，则为80%。 我们对12，866 MRFIT的分析 随机参与者表明，98%的确定率 将通过国家死亡指数来实现 关键时间段和总体死亡确定率 从1974年到1985年，这一比例将提高到95%。 在对这一大群男性进行了10年的随访后， 分析中风和特定部位癌症的危险因素， 完成。 此外，该数据集将用于研究 与单纯收缩期高血压相关的风险， 血清胆固醇和血液中胆固醇水平的地理差异 压力和心血管疾病的周期性。 使用 来自人口普查局的数据（教育和收入水平，按邮编计算 （c）参与者的社会经济地位将 间接估计和冠心病和癌症 白色和黑人之间的死亡率差异将是 由社会阶级来评价。 这个关于危险因素和死亡率结果的数据集是独一无二的 在尺寸和高水平的质量控制方面， 在数据收集过程中。 这些方面使得数据 对于长期跟踪和分析特别有价值。