MORTALITY SURVEILLANCE OF MRFIT SCREENEES

这是一项利用国家死亡指数来确定 361,662名中年男性10年死亡状况 1973-75年进行多危险因素干预筛查 试验中，完成了一些关于关系的分析 舒张压、血清胆固醇与吸烟 因心血管疾病和癌症而死亡，并 对心血管疾病季节变化进行新的分析 风险因素和终点。 到目前为止，该队列中已确认超过17,000人死亡 使用社会保障管理局的数据；死亡 证书已被收集并编码为大约 其中有14,000人死亡。我们估计，仅将SSA用于 生命状况确定，我们将错过25%的死亡 发生在1982-85历年，这段时间是 由于队列的老龄化，死亡率有所增加。 在整个随访期内，死亡率 由于队列的老龄化，增加了。在整个时期内 1974年以来随访死亡确诊率估计 如果使用SSA，则为80%。我们对12,866只MRFIT的分析 随机调查的参与者表明，98%的确认率 将使用国家死亡指数实现这一点 关键时间段，以及总体死亡确认率 从1974年到1985年将增加到95%。 对这一大群男性进行了长达10年的完整随访 卒中危险因素及部位特异性癌症遗嘱分析 才能完成。此外，这个数据集将被用来研究 与单纯收缩期高血压相关的风险，季节性高血压 以及血清胆固醇和血液水平的地理差异 压力和心血管疾病的周期性。vbl.使用 来自人口普查局的数据(按邮编列出的教育和收入水平 代码)，参与者的社会经济地位将是 间接估计与冠心病和癌症 白人和黑人男性之间的死亡率差异将是 按社会阶层进行评估。 这个关于危险因素和死亡结果的数据集是独一无二的 关于规模和高水平的质量控制 在数据收集过程中施加的。这些方面构成了数据 对于长期跟踪和分析特别有价值。

This is a proposal to use the National Death Index to determine the 10 year mortality status of the 361,662 middle-aged men screened in 1973-75 for the Multiple Risk Factor Intervention Trial, to complete a number of analyses on the relationship of diastolic blood pressure, serum cholesterol and cigarette smoking with death from cardiovascular disease and cancer, and to initiate new analyses on the seasonal variation of cardiovascular risk factors and endpoints. Over 17,000 deaths have been identified in this cohort to date using data from the Social Security Administration; death certificates have been collected and coded for approximately 14,000 of these deaths. We estimate that using only the SSA for vital status ascertainment, we will miss 25% of the deaths occurring in calender years 1982-85, a period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up from 1974 the death ascertainment rate is estimated to be 80% if SSA is used. Our analyses with the 12,866 MRFIT randomized participants indicate that a 98% ascertainment rate would be achieved using the National Death Index for this critical time period, and the overall death ascertainment rate from 1974 to 1985 would be increased to 95%. With the complete 10 year follow-up of this large group of men analyses on risk factors from stroke and site specific cancer will be completed. In addition, this data set will be used to study the risks associated with isolated systolic hypertension, the seasonal and geographic variation in levels of serum cholesterol and blood pressure and the cyclic nature of cardiovascular disease. Using data from the Census Bureau (education and income levels by zip code), the socio-economic status of participants will be indirectly estimated and the coronary heart disease and cancer death rate difference between white and black men will be evaluated by social class. This data set on risk factors and mortality outcome is unique with respect to size and to the high level of quality control imposed during data collection. These aspects make the data particularly valuable for long-term follow-up and analysis.