MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
基本信息
- 批准号:3361819
- 负责人:
- 金额:$ 35.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-07-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:alcoholic beverage consumption antihypertensive agents blood pressure body weight cancer prevention cardiovascular disorder epidemiology cardiovascular disorder prevention case history chlorothiazide cholesterol coronary disorder creatinine diabetes mellitus diet therapy disease /disorder proneness /risk electrocardiography emphysema high density lipoproteins human middle age (35-64) human morbidity human mortality hypertension lifestyle longitudinal human study low density lipoprotein lung neoplasms male mathematical model neoplasm /cancer epidemiology nutrition aspect of cancer pathogenic diet prognosis stroke tobacco abuse tobacco abuse prevention triglycerides young adult human (21-34)
项目摘要
The primary goals of this project are to advance understanding of 1) the
long-term cardiovascular disease (CVD) prevention potential of a
multifactor intervention program aimed at cigarette smoking cessation and
the lowering of blood cholesterol and blood pressure and 2) the
relationships of these and other risk factors to cardiovascular and cancer
mortality data through calendar year 1991 (proving 16.5 years of followup)
and analyses of the extensive data set collected during the Multiple Risk
Factor Intervention Trial (MRFIT) and subsequent long-term mortality
followup.
From the screening of over 360,000 men, the MRFIT investigators recruited
12,866 men age 35-57 at above average risk of death from coronary heart
disease (CHD). These men were randomized to a special intervention (SI) or
to a usual care (UC) group. At the conclusion of the trial in 1982, the SI
men compared to UC men had a 7.1% lower CHD death rate, a 4.7% lower CVD
death rate, and a 2.1% higher death rate from all causes. None of these
differences were statistically significant. Since 1982, numerous
scientific reports have been published based on data collected during the
trial. Recently, data have become available to bring the average duration
of mortality followup to 10.5 years. At the time of this extended followup,
the SI men compared to UC men had a 10.2% lower CHD death rate (a 24.3%
lower rate for acute MI), and 8.3% lower CVD death rate and a 7.7% lower
death rate from all causes. With the exception of the significant
difference for acute MI., these differences approach but do not attain
statistical significance.
It is proposed to examine intervention efficacy and the relationships of
the various risk factors to mortality form CVD (including stroke) and major
sites of cancers analyses based on 16 year followup data that could not be
done previously because of small numbers of deaths for some causes of death
and for some subgroups of the population. Data collected during the MRFIT
on smoking habits, blood pressure, lipids, diet, drug treatment,
electrocardiography and other risk factors are among the most detailed and
carefully controlled for quality among large epidemiologic studies.
该项目的主要目标是增进对 1) 的理解
长期预防心血管疾病(CVD)的潜力
旨在戒烟的多因素干预计划
降低血液胆固醇和血压,2)
这些和其他危险因素与心血管和癌症的关系
1991日历年的死亡率数据(经过16.5年的追踪证明)
以及对多重风险期间收集的广泛数据集的分析
因素干预试验 (MRFIT) 和随后的长期死亡率
后续行动。
MRFIT 调查人员从超过 360,000 名男性的筛查中招募了
12,866 名 35-57 岁男性死于冠心病的风险高于平均水平
疾病(冠心病)。 这些人被随机分配接受特殊干预(SI)或
至常规护理 (UC) 组。 1982 年审判结束时,SI
与 UC 男性相比,男性的 CHD 死亡率降低 7.1%,CVD 死亡率降低 4.7%
死亡率,全因死亡率增加 2.1%。这些都没有
差异有统计学意义。 自 1982 年以来,无数
已根据期间收集的数据发表了科学报告
审判。 最近,数据显示平均持续时间
死亡率随访至 10.5 年。在本次延长随访时,
与 UC 男性相比,SI 男性的 CHD 死亡率低 10.2%(24.3%
急性心肌梗死率降低),CVD 死亡率降低 8.3%,CVD 死亡率降低 7.7%
所有原因造成的死亡率。 除了显着的
急性心肌梗死的差异,这些差异接近但未达到
统计显着性。
建议检查干预效果及其关系
CVD(包括中风)和重大疾病导致死亡的各种危险因素
基于 16 年随访数据的癌症部位分析,但这些数据无法
之前因某些死因造成的死亡人数较少而进行过
以及某些人口亚群体。 MRFIT 期间收集的数据
关于吸烟习惯、血压、血脂、饮食、药物治疗、
心电图和其他危险因素是最详细和最详细的。
在大型流行病学研究中仔细控制质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARCUS O KJELSBERG其他文献
MARCUS O KJELSBERG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARCUS O KJELSBERG', 18)}}的其他基金
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361820 - 财政年份:1990
- 资助金额:
$ 35.76万 - 项目类别:
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361821 - 财政年份:1990
- 资助金额:
$ 35.76万 - 项目类别:
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361818 - 财政年份:1990
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317022 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317034 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317060 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317024 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317029 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317021 - 财政年份:1984
- 资助金额:
$ 35.76万 - 项目类别:
相似海外基金
The role of antihypertensive agents in renal and vascular complications in a model of hypertension and diabetes
抗高血压药物在高血压和糖尿病模型中肾脏和血管并发症中的作用
- 批准号:
nhmrc : 145854 - 财政年份:2001
- 资助金额:
$ 35.76万 - 项目类别:
NHMRC Postgraduate Scholarships
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
- 批准号:
6125791 - 财政年份:1997
- 资助金额:
$ 35.76万 - 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
- 批准号:
2487342 - 财政年份:1997
- 资助金额:
$ 35.76万 - 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
- 批准号:
2839029 - 财政年份:1997
- 资助金额:
$ 35.76万 - 项目类别:
APPROACHES TO NATRIURETIC AND ANTIHYPERTENSIVE AGENTS
利尿钠和抗高血压药物的治疗方法
- 批准号:
6330091 - 财政年份:1997
- 资助金额:
$ 35.76万 - 项目类别:
Antihypertensive Agents of Kudzu: Possible Chemical Utilization of a Southeastern Pest Vine
葛根的抗高血压剂:东南部害虫藤蔓的可能化学利用
- 批准号:
7905238 - 财政年份:1979
- 资助金额:
$ 35.76万 - 项目类别:
Standard Grant