MORTALITY SURVEILLANCE OF MRFIT SCREENEES

这是一项确定361，622名35-57岁男性死亡率的建议 在多重风险因素的初步筛查中被发现的人 干预试验（MRFIT）通过10年随访。 使用 由社会保障局（SSA）提供的死亡地点， 将与州卫生部门联系， 证书. 当前5年全因和特定原因死亡率数据 都是可用的。 截至本补助期结束时死亡率数据 6年后，所有男性都可以使用。 这项建议 代表了目前赠款的延续，将采用方法 建立在目前的赠款，并将允许更明确的分析 两个主要的研究问题：1）协会 导致特定癌症死亡率和血清胆固醇浓度，以及2） 血清胆固醇、舒张压和 吸烟与冠心病死亡率的关系， 黑人和白色男人的脑血管疾病。 对于第一个问题，这一组代表了最大的前景 队列研究尚未分析。 额外的数据将允许比较 血清胆固醇与癌症死亡率之间关系 不同的癌症部位 除了胆固醇-癌症问题和黑色的比较， 和白色男性的主要危险因素与心血管 终点，进一步研究风险预测的发展 方程，以及与使用SSA数据有关的方法学问题 档案和国家死亡指数将进行。

This is a proposal to ascertain the mortality of the 361,622 men aged 35-57 who were seen at the initial screening of the Multiple Risk Factor Intervention Trial (MRFIT) through 10 years of follow-up. Using the location of death supplied by the Social Security Administration (SSA), state departments of health will be contacted to obtain death certificates. Currently 5 year all cause and cause-specific mortality data are available. By the end of the current grant period mortality data through 6 years will be available for all men. This proposal, which represents a continuation of the current grant, will employ methods established in the current grant and will permit more definitive analyses to be performed on two major research questions: 1) the associations of cause specific cancer mortality and serum cholesterol concentration, and 2) the association of serum cholesterol, diastolic blood pressure and cigarettes per day with mortality from coronary heart disease, and cerebrovascular disease for black and white men. For the first question, this group represents the largest prospective cohort study yet analyzed. The additional data will allow comparisons of the association of serum cholesterol and cancer mortality to be made for different cancer sites. In addition to the cholesterol-cancer question and the comparison of black and white men in the association of major risk factors with cardiovascular endpoints, further investigations on the development of risk prediction equations, and on methodological issues associated with using SSA data files and the National Death Index will be carried out.