MORTALITY SURVEILLANCE OF MRFIT SCREENEES

这是一项旨在确定361,622名年龄在35岁至57岁之间的男性死亡率的建议 在多重风险因素的初步筛查中被看到的人 干预试验(MRFIT)通过10年的随访。使用 死亡地点由社会保障管理局(SSA)提供， 将与州卫生部门联系以获得死亡 证书。目前5年所有原因和特定原因的死亡率数据 都是可用的。截至当前授权期结束时的死亡率数据 所有男性都可以享受到6年的时间。这项建议，即 表示当前授予的延续，将使用 在目前的赠款中建立，并将允许进行更明确的分析 将在两个主要研究问题上进行：1) 导致特定癌症死亡率和血清胆固醇浓度，以及2) 血清胆固醇、舒张压与高血压的关系 每天吸烟与冠心病死亡率的关系，以及 黑人和白人男性的脑血管疾病。 对于第一个问题，这一群体代表着最大的潜在客户 队列研究尚未分析。额外的数据将允许比较 血清胆固醇与癌症死亡率的关系有待研究 不同的癌症部位。 除了胆固醇-癌症问题和黑色的比较 白人男性在主要危险因素与心血管疾病的关联中 端点，进一步研究风险预测的发展 方程式，以及与使用SSA数据相关的方法学问题 将开展档案和全国死亡指数工作。

This is a proposal to ascertain the mortality of the 361,622 men aged 35-57 who were seen at the initial screening of the Multiple Risk Factor Intervention Trial (MRFIT) through 10 years of follow-up. Using the location of death supplied by the Social Security Administration (SSA), state departments of health will be contacted to obtain death certificates. Currently 5 year all cause and cause-specific mortality data are available. By the end of the current grant period mortality data through 6 years will be available for all men. This proposal, which represents a continuation of the current grant, will employ methods established in the current grant and will permit more definitive analyses to be performed on two major research questions: 1) the associations of cause specific cancer mortality and serum cholesterol concentration, and 2) the association of serum cholesterol, diastolic blood pressure and cigarettes per day with mortality from coronary heart disease, and cerebrovascular disease for black and white men. For the first question, this group represents the largest prospective cohort study yet analyzed. The additional data will allow comparisons of the association of serum cholesterol and cancer mortality to be made for different cancer sites. In addition to the cholesterol-cancer question and the comparison of black and white men in the association of major risk factors with cardiovascular endpoints, further investigations on the development of risk prediction equations, and on methodological issues associated with using SSA data files and the National Death Index will be carried out.