MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN

本项目的主要目标是增进对1) 长期预防心血管疾病(CVD)的潜力 旨在戒烟和吸烟的多因素干预计划 降低血胆固醇和血压；2) 这些危险因素和其他危险因素与心血管疾病和癌症的关系 1991年历年死亡率数据(16.5年随访证明) 以及对在多重风险期间收集的大量数据集的分析 因素干预试验(MRFIT)与随后的长期死亡率 后续行动。 从对超过36万名男性的筛查中，MRFIT调查人员招募了 年龄在35-57岁之间的12,866名男性冠心病死亡风险高于平均水平 疾病(CHD)。这些人随机接受特殊干预(SI)或 至常规护理(UC)组。在1982年审判结束时，SI 与UC相比，男性的冠心病死亡率低7.1%，心血管疾病低4.7% 死亡率上升，全死因死亡率上升2.1%。这些都不是 差异有统计学意义。自1982年以来，有许多 科学报告的发表是基于在 审判。最近，已经有数据可以带来平均持续时间 死亡率随访至10.5年。在这次延长的后续行动中， 与UC男性相比，SI男性的冠心病死亡率低10.2%(24.3% 急性心肌梗死的发生率更低)，心血管疾病死亡率降低8.3%，降低7.7% 各种原因造成的死亡率。除了重要的 对于急性心肌梗死，这些差异接近但没有达到 统计学意义。 建议检查干预效果和 心脑血管疾病(包括卒中)和重大疾病死亡的各种危险因素 基于16年随访数据的癌症部位分析 以前是因为一些死因的少量死亡而做的 对于人口中的一些亚群来说。在MRFIT期间收集的数据 关于吸烟习惯，血压，血脂，饮食，药物治疗， 心电图和其他危险因素是最详细和 在大型流行病学研究中仔细控制质量。

The primary goals of this project are to advance understanding of 1) the long-term cardiovascular disease (CVD) prevention potential of a multifactor intervention program aimed at cigarette smoking cessation and the lowering of blood cholesterol and blood pressure and 2) the relationships of these and other risk factors to cardiovascular and cancer mortality data through calendar year 1991 (proving 16.5 years of followup) and analyses of the extensive data set collected during the Multiple Risk Factor Intervention Trial (MRFIT) and subsequent long-term mortality followup. From the screening of over 360,000 men, the MRFIT investigators recruited 12,866 men age 35-57 at above average risk of death from coronary heart disease (CHD). These men were randomized to a special intervention (SI) or to a usual care (UC) group. At the conclusion of the trial in 1982, the SI men compared to UC men had a 7.1% lower CHD death rate, a 4.7% lower CVD death rate, and a 2.1% higher death rate from all causes. None of these differences were statistically significant. Since 1982, numerous scientific reports have been published based on data collected during the trial. Recently, data have become available to bring the average duration of mortality followup to 10.5 years. At the time of this extended followup, the SI men compared to UC men had a 10.2% lower CHD death rate (a 24.3% lower rate for acute MI), and 8.3% lower CVD death rate and a 7.7% lower death rate from all causes. With the exception of the significant difference for acute MI., these differences approach but do not attain statistical significance. It is proposed to examine intervention efficacy and the relationships of the various risk factors to mortality form CVD (including stroke) and major sites of cancers analyses based on 16 year followup data that could not be done previously because of small numbers of deaths for some causes of death and for some subgroups of the population. Data collected during the MRFIT on smoking habits, blood pressure, lipids, diet, drug treatment, electrocardiography and other risk factors are among the most detailed and carefully controlled for quality among large epidemiologic studies.