MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN

该项目的主要目标是促进对1） 长期心血管疾病（CVD）预防潜力 多因素干预计划，旨在戒烟， 降低血液胆固醇和血压，以及2） 这些和其他危险因素与心血管和癌症的关系 截至1991日历年的死亡率数据（证明随访16.5年） 和分析在多重风险评估期间收集的大量数据集， 因素干预试验（MRFIT）和随后的长期死亡率 跟进。 MRFIT调查人员从36万多名男性中招募了 12，866名年龄在35-57岁之间的男性死于冠心病的风险高于平均水平 冠心病（CHD）。 这些男性被随机分配到特殊干预（SI）或 常规护理组（UC）。 在1982年审判结束时， 与UC男性相比，男性CHD死亡率低7.1%，CVD低4.7%， 死亡率和2.1%的高死亡率的所有原因。没有这些 差异有统计学意义。 自1982年以来， 科学报告是根据在2000年期间收集的数据发表的。 审判 最近，有数据显示， 死亡率随访10.5年。在这次延长的随访中， 与UC男性相比，SI男性的CHD死亡率低10.2%（24.3%）。 急性心肌梗死发生率降低），心血管疾病死亡率降低8.3%， 所有原因的死亡率。 除了重要的 急性心肌梗死的差异，这些差异接近但达不到 统计显著性 建议检查干预效果和 CVD（包括中风）和主要 基于16年随访数据的癌症部位分析， 由于某些死因导致的死亡人数较少， 以及一些亚群体的情况。 MRFIT期间收集的数据 吸烟习惯，血压，血脂，饮食，药物治疗， 心电图和其他风险因素是最详细的， 在大型流行病学研究中严格控制质量。

The primary goals of this project are to advance understanding of 1) the long-term cardiovascular disease (CVD) prevention potential of a multifactor intervention program aimed at cigarette smoking cessation and the lowering of blood cholesterol and blood pressure and 2) the relationships of these and other risk factors to cardiovascular and cancer mortality data through calendar year 1991 (proving 16.5 years of followup) and analyses of the extensive data set collected during the Multiple Risk Factor Intervention Trial (MRFIT) and subsequent long-term mortality followup. From the screening of over 360,000 men, the MRFIT investigators recruited 12,866 men age 35-57 at above average risk of death from coronary heart disease (CHD). These men were randomized to a special intervention (SI) or to a usual care (UC) group. At the conclusion of the trial in 1982, the SI men compared to UC men had a 7.1% lower CHD death rate, a 4.7% lower CVD death rate, and a 2.1% higher death rate from all causes. None of these differences were statistically significant. Since 1982, numerous scientific reports have been published based on data collected during the trial. Recently, data have become available to bring the average duration of mortality followup to 10.5 years. At the time of this extended followup, the SI men compared to UC men had a 10.2% lower CHD death rate (a 24.3% lower rate for acute MI), and 8.3% lower CVD death rate and a 7.7% lower death rate from all causes. With the exception of the significant difference for acute MI., these differences approach but do not attain statistical significance. It is proposed to examine intervention efficacy and the relationships of the various risk factors to mortality form CVD (including stroke) and major sites of cancers analyses based on 16 year followup data that could not be done previously because of small numbers of deaths for some causes of death and for some subgroups of the population. Data collected during the MRFIT on smoking habits, blood pressure, lipids, diet, drug treatment, electrocardiography and other risk factors are among the most detailed and carefully controlled for quality among large epidemiologic studies.