MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
基本信息
- 批准号:3361821
- 负责人:
- 金额:$ 40.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-07-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:alcoholic beverage consumption antihypertensive agents blood pressure body weight cancer prevention cardiovascular disorder epidemiology cardiovascular disorder prevention case history chlorothiazide cholesterol coronary disorder creatinine diabetes mellitus diet therapy disease /disorder proneness /risk electrocardiography emphysema high density lipoproteins human middle age (35-64) human morbidity human mortality human subject hypertension lifestyle longitudinal human study low density lipoprotein lung neoplasms male mathematical model neoplasm /cancer epidemiology nutrition aspect of cancer nutrition related tag pathogenic diet prognosis stroke tobacco abuse tobacco abuse prevention triglycerides young adult human (21-34)
项目摘要
The primary goals of this project are to advance understanding of 1) the
long-term cardiovascular disease (CVD) prevention potential of a
multifactor intervention program aimed at cigarette smoking cessation and
the lowering of blood cholesterol and blood pressure and 2) the
relationships of these and other risk factors to cardiovascular and cancer
mortality data through calendar year 1991 (proving 16.5 years of followup)
and analyses of the extensive data set collected during the Multiple Risk
Factor Intervention Trial (MRFIT) and subsequent long-term mortality
followup.
From the screening of over 360,000 men, the MRFIT investigators recruited
12,866 men age 35-57 at above average risk of death from coronary heart
disease (CHD). These men were randomized to a special intervention (SI) or
to a usual care (UC) group. At the conclusion of the trial in 1982, the SI
men compared to UC men had a 7.1% lower CHD death rate, a 4.7% lower CVD
death rate, and a 2.1% higher death rate from all causes. None of these
differences were statistically significant. Since 1982, numerous
scientific reports have been published based on data collected during the
trial. Recently, data have become available to bring the average duration
of mortality followup to 10.5 years. At the time of this extended followup,
the SI men compared to UC men had a 10.2% lower CHD death rate (a 24.3%
lower rate for acute MI), and 8.3% lower CVD death rate and a 7.7% lower
death rate from all causes. With the exception of the significant
difference for acute MI., these differences approach but do not attain
statistical significance.
It is proposed to examine intervention efficacy and the relationships of
the various risk factors to mortality form CVD (including stroke) and major
sites of cancers analyses based on 16 year followup data that could not be
done previously because of small numbers of deaths for some causes of death
and for some subgroups of the population. Data collected during the MRFIT
on smoking habits, blood pressure, lipids, diet, drug treatment,
electrocardiography and other risk factors are among the most detailed and
carefully controlled for quality among large epidemiologic studies.
该项目的主要目标是促进对1)
长期心血管疾病(CVD)预防潜力
多因素干预计划,旨在戒烟,
降低血胆固醇和血压; 2)
这些和其他危险因素与心血管和癌症的关系
截至1991日历年的死亡率数据(证明随访16.5年)
和分析在多重风险评估期间收集的大量数据集,
因素干预试验(MRFIT)和随后的长期死亡率
跟进。
MRFIT调查人员从36万多名男性中招募了
12,866名年龄在35-57岁之间的男性死于冠心病的风险高于平均水平
疾病(CHD)。 这些男性被随机分配到特殊干预(SI)或
常规护理组(UC)。 在1982年审判结束时,
与UC男性相比,男性CHD死亡率低7.1%,CVD低4.7%,
死亡率和2.1%的高死亡率的所有原因。没有这些
差异有统计学意义。 自1982年以来,
科学报告是根据在2000年期间收集的数据发表的。
审判 最近,有数据显示,
死亡率随访10.5年。在这次延长的随访中,
与UC男性相比,SI男性的CHD死亡率低10.2%(24.3%)。
急性心肌梗死发生率降低),心血管疾病死亡率降低8.3%,
所有原因的死亡率。 除了重要的
急性心肌梗死的差异,这些差异接近但达不到
统计显著性
建议检查干预效果和
CVD(包括中风)和主要
基于16年随访数据的癌症部位分析,
由于某些死因导致的死亡人数较少,
以及一些亚群体的情况。 MRFIT期间收集的数据
吸烟习惯,血压,血脂,饮食,药物治疗,
心电图和其他风险因素是最详细的,
在大型流行病学研究中严格控制质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARCUS O KJELSBERG其他文献
MARCUS O KJELSBERG的其他文献
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{{ truncateString('MARCUS O KJELSBERG', 18)}}的其他基金
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361820 - 财政年份:1990
- 资助金额:
$ 40.21万 - 项目类别:
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361818 - 财政年份:1990
- 资助金额:
$ 40.21万 - 项目类别:
MORTALITY FOLLOW-UP AND ANALYSIS--MRFIT RANDOMIZED MEN
死亡率随访与分析--MRFIT随机男性
- 批准号:
3361819 - 财政年份:1990
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317034 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317022 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317021 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317060 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317024 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
EARLY INTERVENTION/CHRONIC OBSTRUCTIVE PULMONARY DISEASE
早期干预/慢性阻塞性肺疾病
- 批准号:
2317029 - 财政年份:1984
- 资助金额:
$ 40.21万 - 项目类别:
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