ELECTROVENTILATION

该提案寻求支持，以创建一种新型通风机， 通过对运动神经和肌肉的电刺激进行操作， 呼吸，使用放置在胸部的皮肤表面电极。 列车 使用非常短持续时间的电刺激， 刺激不会发生。 我们称这种技术为 电通气（EV）。 选择性刺激的秘密 呼吸，而不是心脏肌肉和自主神经，在于使用 非常短的脉冲，利用膜时间的差异 心肌和呼吸神经之间的常数。 初步 研究表明，电通气在肺内产生大量的潮气量， 麻醉犬，超过正常静息潮气量数倍。 这项研究包括对狗、猪和狒狒的研究， 最佳刺激模式和电极位置。 我们还建议创建和评估一个实验需求 电呼吸机，通过阻抗法监测吸气 如果不存在，则自动开始电通气。 一 特殊的电子设计将保持监测的能力， 电通气期间的心电图。 电动通风机将 还包括电极断开报警。 决胜阶段 研究（将在未来的提案中解决），将对该设备进行测试 麻醉状态下的病人

This proposal seeks support to create a new type of ventilator which operates by electrical stimulation of the motor nerves and muscles of respiration, using skin-surface electrodes placed on the chest. Trains of very short-duration electrical stimuli are used so that unwanted cardiac stimulation will not occur. We have termed this technique electroventilation (EV). The secret of selective stimulation of respiratory, but not heart muscle and autonomic nerves, lies in the use of very short-duration pulses, which exploit differences in membrane time constants between cardiac muscle and respiratory nerves. Preliminary studies show that electroventilation produces substantial tidal volumes in the anesthetized dog, exceeding normal resting tidal volume several fold. The research involves studies on dog, pigs, and baboons to work out details of the optimum stimulus patterns and electrode locations. We also propose to create and evaluate an experimental demand electroventilator, which will monitor inspiration by the impedance method and, if it is not present, begin electroventilation automatically. A special electronic design will preserve the ability to monitor the electrocardiogram during electroventilation. The electroventilator will also include alarms for electrode disconnection. In the final stage of research (to be addressed in a future proposal), the device will be tested in patients under anesthesia.