PRESSURE MONITORING SYSTEM FOR BLOOD PRESSURE CONTROL

拟议的研究构成了我们实现目标的第二步， 创造一个完全植入的药物输送系统， 控制血压。 第一步已经完成， 表明动脉脉搏波速度（PWV）跟踪舒张 压力，从而消除了对可植入的 压力传感器 本文提出的研究旨在 证明PWV可以可靠地指示慢性 正常和高血压动物。 拟进行的研究将使用植入了 通过测量阻抗降低来检测脉冲的电极 在一对动脉周围电极之间。 四对电极将 检查不同部位脉搏的适宜性 感应 将选择三个最佳动脉部位进行慢性 PWV与血压关系的研究。 我们有 已经开发出一种算法， 两个动脉脉搏之间的差异，并将此时间缩放到PWV。 血压正常者和高血压患者的血压与PWV具有相关性 动物，用运动来增加血压。 此外该 动物将被镇静，并将使用药物进行关联，以提高 降低血压 最后，在那些将要被 在电极成熟研究中，将进行相关性分析 在更大范围的压力下使用药物。 在所有研究中，我们将展示 PWV（实际上是脉搏传导时间的倒数）跟踪舒张压， 压力，因此可以作为控制和 自动植入式血压控制器。

The proposed research constitutes the second step toward our goal of creating a completely implanted drug-delivery system for the automatic control of blood pressure. The first step has been completed and demonstrated that arterial pulse-wave velocity (PWV) tracks diastolic pressure faithfully, thereby eliminating the need for an implantable pressure transducer. The research proposed herein is designed to demonstrate that PWV can reliably indicate blood pressure in the chronic normo- and hypertensive animal. The studies to be conducted will employ large dogs with implanted electrodes to detect the pulse by measurement of the impedance decrease between a pair of periarterial electrodes. Four pairs of electrodes will be implanted to examine the appropriateness of different sites for pulse sensing. The three best arterial sites will be selected for the chronic studies of the relationship between PWV and blood pressure. We have already developed an algorithm that measures the beat-by-beat time difference between two arterial pulses and scales this time to PWV. Blood pressure and PWV will be correlated in normotensive and hypertensive animals, with exercise to increase blood pressure. In addition, the animals will be sedated and correlations will be made using drugs to raise and lower blood pressure. Finally, in those animals that are to be sacrificed for the electrode-maturation studies, correlations will be made over a wider range of pressure using drugs. In all studies, we will show that PWV (actually the reciprocal of pulse transit time) tracks diastolic pressure, and therefore can serve as an adequate signal for controlling and automatic implanted blood-pressure controller.