Anti-Biofilm Materials Using Multifunctional MOFs

使用多功能 MOF 的抗生物膜材料

• 批准号: EP/I028080/1
• 负责人: Russell Morris
• 金额: $ 19.48万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI028080%2F1
• 关键词: Anti; Biofilm; Materials; Using; Multifunctional

Biofilm infections are a major source of nosocomial (hospital-acquired) infections, accounting for ~65% of all those treated in the Western world (according to an estimate in 1999 ). Almost a defining feature of biofilms is their increased resistance to both antimicrobial drugs and to the host animal's own defences. This makes them particularly difficult targets, and even strains of microbe that are effectively treated when in their non-biofilm (planktonic) form are often untreatable when formed in biofilms. There is therefore a great incentive to develop new methods of combating such infections. In this project we will look to develop the commercial and technical aspects of a technology that we originally developed during an EPSRC-funded research projects (GR/T09705/01 Designing Porous Metal-Organic Frameworks to Store and Deliver Large Amounts of Nitric Oxide). We have proven that nitric oxide delivered from metal organic frameworks, a type of highly porous inorganic organic hybrid material, is extremely potent at killing bacteria, even when the bacteria have formed biofilm communities. We have also shown that, because of the very highly porous nature of the metal organic frameworks, we can load drugs or other small molecules simultaneously with the NO. In this project we aim to develop the commercial potential of these materials with a goal of developing a product for the anti-biofilm market. In particular our previous results have shown that we can formulate these materials into polymers suitable for coating medical devices. Over the course of this project we will coat commercial devices with MOF-containing polymers and prove their anti-biofilm activity under industry standard conditions. We will also develop a commercialisation for this technology in the anti-biofilm area as well as improving the strength of our intellectual property and identifying important potential commercial partners.

生物膜感染是医院感染的主要来源，占西方世界所有治疗患者的65%（根据1999年的估计）。生物膜的几乎一个决定性特征是它们对抗微生物药物和宿主动物自身防御的抗性增加。这使得它们成为特别困难的目标，并且即使是在其非生物膜（非生物膜）形式时被有效处理的微生物菌株在形成生物膜时也常常是不可处理的。因此，有很大的动力来开发防治这种感染的新方法。在这个项目中，我们将寻求开发我们最初在EPSRC资助的研究项目（GR/T09705/01设计多孔金属有机框架以储存和提供大量一氧化氮）中开发的技术的商业和技术方面。我们已经证明，从金属有机框架（一种高度多孔的无机有机混合材料）中释放的一氧化氮在杀死细菌方面非常有效，即使细菌已经形成生物膜群落。我们还表明，由于金属有机框架具有非常高的多孔性，我们可以与NO同时负载药物或其他小分子。在该项目中，我们的目标是开发这些材料的商业潜力，目标是开发抗生物膜市场的产品。特别是我们之前的结果表明，我们可以将这些材料配制成适用于涂覆医疗器械的聚合物。在这个项目的过程中，我们将用含MOF的聚合物涂覆商业设备，并在行业标准条件下证明其抗生物膜活性。我们还将在抗生物膜领域开发该技术的商业化，并提高我们的知识产权实力，并确定重要的潜在商业合作伙伴。

项目成果

Metal-organic frameworks as potential multi-carriers of drugs

• DOI: 10.1039/c3ce41289j
• 发表时间: 2013-01-01
• 期刊: CRYSTENGCOMM
• 影响因子: 3.1
• 作者: Rojas, Sara;Wheatley, Paul S.;Barea, Elisa
• 通讯作者: Barea, Elisa