A LONGITUDINAL STUDY IN PSYCHIATRIC EPIDEMIOLOGY

精神病流行病学的纵向研究

• 批准号: 3377433
• 负责人: JANE M MURPHY
• 金额: $ 4.47万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3377433
• 关键词: Canada; adult human (21+); clinical anxiety; clinical depression; computer assisted diagnosis; disease /disorder proneness /risk; human subject; longitudinal human study; mental health epidemiology; mental health information system; patient /disease registry; questionnaires; rural area

This application concerns the completion of a longitudinal study of psychiatric epidemiology as it relates to data already collected for the period 1952 to 1970 and then extension through the gathering of new data about the period 1970 to 1990. Named the Stirling County Study, the investigation involves multiple cross- sectional surveys and several cohort follow-up studies pertinent to 2848 adult residents of a rapidly changing rural environment in Atlantic Canada. The objectives of the study are to contribute information on trends in prevalence, incidence, outcomes (mortality and morbidity), and treatment of psychiatric disorders in a general population and to relate these variables to risk factors about physical health, life events, and social conditions. The data consist in: 1) self-report of symptoms, impairment, and duration of depression and anxiety disorders through structured questionnaire interviews; 2) reports by general physicians about the full range of psychiatric disorders; 3) a case register of a local mental health center; and 4) death certificates. A diagnostic computer program was written for analyzing information given by subjects. Using this methodology, it was found that during the period from 1952 through 1970 the prevalence of depression and anxiety remained at a stable rate of 12 cases per 100 persons and the incidence of these disorders was, on the average, nine cases per 1000 persons per year. Depression has consistently been distinguished from anxiety, including the fact that depression was found to have significantly worse outcome in terms of both mortality and morbidity. Life table methods, log-linear analysis, and survival regressions are used for calculating rates and testing the significance of associations with risk factors. The application includes research directed toward comparing findings from this investigation with those from other places study, both urban and rural. The degree of concordance between the interview methods of this study and those of more recent studies will be assessed by using the Diagnostic Interview Schedule along with the Stirling Study Schedule in the follow-up interviews to be carried out in 1990.

本申请涉及完成一项纵向研究 精神病流行病学，因为它涉及到已经收集的数据， 从1952年到1970年， 收集1970年至1990年期间的新数据。 评为 斯特林县的研究，调查涉及多个交叉- 部分调查和几项队列随访研究， 2848名成年居民在一个快速变化的农村环境中， 大西洋加拿大。 这项研究的目的是提供以下方面的资料： 流行率、发病率、结果（死亡率和 发病率），以及一般精神疾病的治疗 并将这些变量与风险因素联系起来， 身体健康、生活事件和社会状况。 数据 包括：1）自我报告症状、损伤和持续时间 抑郁症和焦虑症的治疗 问卷调查; 2）一般医生的报告 精神疾病的全部范围; 3）当地一个 精神卫生中心; 4）死亡证明。 编写了诊断计算机程序， 受试者提供的信息。 使用这种方法， 发现在1952年到1970年期间， 抑郁症和焦虑症的患病率保持稳定， 12例/100人，这些疾病的发病率为， 平均每年每1000人有9宗个案。 抑郁 一直被区别于焦虑，包括 事实上，抑郁症被发现有显着恶化 在死亡率和发病率方面的结果。 生命表 方法，对数线性分析和生存回归用于 计算比率并检验与下列因素的关联的重要性： 危险因素 该应用程序包括针对比较的研究 这次调查的结果与其他地方的调查结果 研究，城市和农村。 之间的一致性程度 本研究的访谈方法和最近的访谈方法 研究将通过使用诊断访谈进行评估 随访时，计划沿着斯特林研究计划 1990年进行的采访。