LONGITUDINAL STUDY IN PSYCHIATRIC EPIDEMIOLOGY

精神病流行病学的纵向研究

• 批准号: 2717293
• 负责人: JANE M MURPHY
• 金额: $ 38.89万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2717293
• 关键词: Canada; aging; alcoholism /alcohol abuse; attitude; clinical anxiety; clinical depression; clinical research; disease /disorder proneness /risk; drug abuse; family genetics; gender difference; health care policy; human mortality; human subject; interview; lifestyle; longitudinal human study; mental disorder diagnosis; mental health epidemiology; organic brain syndrome; personality disorders; prognosis; relapse /recurrence; sex roles; socioeconomics

The purpose of this proposal is to build on information gathered recently as part of a longitudinal investigation of psychiatric epidemiology among adult samples of a general population. The overall objective is to provide a 40-year perspective on historical trends regarding psychiatric disorders. The site in Atlantic Canada has been given the pseudonym of "Stirling County" for protection of identity. The specific aims are to continue analysis of the accumulated body of data and to prepare a series of reports in which findings from the study will be described and, where appropriate, compared with those of recent studies. The study involves three repeated cross-sectional sample surveys (1952, 1970, and 1992) and two panel follow-up intervals (1952-1970- and 1970- 1992). Time trends will be reported regarding prevalence, incidence, clinical course, and mortality outcomes among approximately 4000 subjects. Two types of information have been gathered from the beginning of the investigation: 1.) structured interviews with subjects concerning depression, anxiety, and medical conditions.; and 2.) semi-structured interviews by psychiatrists with general physicians who have been named by subjects and asked about the medical and psychiatric histories of these subjects. The recent wave of data-gathering included administration of sections of the NIMH Diagnostic Interview Schedule and the Modified Mini-Mental Status Examination. Findings from these schedules will aid comparison to studies such as the NIMH Epidemiologic Catchment Area Program and the National Comorbidity Study, especially for common disorders such as those involving depression, anxiety, alcohol abuse, and cognitive dysfunction associated with aging. The risk factors and trends to be investigated include: birth cohort effects, aging, gender, changes in the role of women, socio-economic status, family history of psychiatric disorders, marriage and family patterns, religious/ethnic identity, and comorbidity between psychiatric and medical disorders and also within the psychiatric spectrum. The effects of health policy changes will be investigated since Canadian national health insurance was introduced into the area at the mid-point of the study interval. Analysis of data will make use of multivariate techniques such as loglinear analysis, survival regressions, and structural equation modelling. Reliability and validity of psychiatric diagnoses will be assessed.

这项建议的目的是根据最近收集的资料 作为精神病学纵向调查的一部分， 一般人群的成人样本。 总体目标是提供 关于精神疾病历史趋势的40年展望。 这个位于加拿大大西洋沿岸的网站被赋予了“斯特林”的笔名 为了保护身份。 具体目标是继续 分析积累的大量数据并编写一系列报告 其中将描述研究结果，并在适当情况下， 与最近的研究相比。 这项研究涉及三个重复的横截面抽样调查（1952年， 1970年和1992年）和两个小组随访期（1952-1970年和1970- 1992年）。 将报告患病率、发生率、 在大约4000名受试者中的临床过程和死亡率结果。 从一开始就收集了两种类型的信息， 调查：1。） 结构化访谈， 抑郁、焦虑和身体状况。和2.）半结构 精神病学家与被提名的普通医生的访谈 并询问这些受试者的医疗和精神病史 科目 最近的数据收集浪潮包括管理 NIMH诊断访谈表和改良简易精神状态量表 考试 这些时间表的结果将有助于与研究进行比较 如NIMH流行病学集水区计划和国家 合并症研究，特别是常见疾病，如涉及 抑郁、焦虑、酗酒和认知功能障碍相关 随着年龄的增长。 需要调查的风险因素和趋势包括： 影响、老龄化、性别、妇女作用的变化、社会经济 状态、精神疾病家族史、婚姻和家庭 模式、宗教/种族身份以及精神疾病之间的共病性 和医学疾病以及精神疾病。 的 将调查自加拿大以来卫生政策变化的影响 国家健康保险是在2000年中期引入该地区的。 研究间隔。 数据分析将利用多变量 技术，如对数线性分析，生存回归，和结构 方程建模 精神病诊断的信度和效度将 被评估。