A LONGITUDIAL STUDY IN PSYCHIATRIC EPIDEMIOLOGY

精神病流行病学的纵向研究

• 批准号: 3377432
• 负责人: JANE M MURPHY
• 金额: $ 93.05万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3377432
• 关键词: Canada; clinical anxiety; clinical depression; cognition disorders; computer assisted diagnosis; disease /disorder proneness /risk; human subject; longitudinal human study; mental health epidemiology; prognosis; relapse /recurrence; rural area; statistics /biometry; urban area

This application concerns the extension of a longitudinal study in psychiatric epidemiology (the Stirling County Study in Atlantic Canada) so that it will provide a 40-year perspective on the prevalence, incidence, clinical outcomes, and mortality risk associated with psychiatric disorders. Consistent data-collection procedures were used to study representative samples of adults in 1952, 1962-64, and 1970. In each field phase after the first, the same procedures were used to conduct follow-up investigations of individuals who had entered the study earlier. These procedures involve interviewing subjects with a structured schedule that covers depression, anxiety, physical health, and socio-demographic factors along with interviewing general physicians about the psychiatric and medical histories of the same subjects. The specific aims of the research are to: 1.) select and investigate a new sample of 1350 subjects representing the adults of Stirling County in 1992; 2.) locate and re-interview 1400 former subjects expected to be alive in 1992; 3.) gather mortality information about the approximately 950 former subjects who can be expected to have died; and 4). expand the interview protocol to include portions of the Diagnostic Interview Schedule (DIS) and, for persons 65 years and older, the Modified Mini-Mental State Examination. The purpose of the latter additions is to lay the foundation for comparing findings from this study with those from the five U.S. sites of NIMH's Epidemiologic Catchment Area (ECA) Program, those from a similar study in Edmonton, Canada, and those to be derived from a national study in Canada of the epidemiology of cognitive impairment. Diagnostic computer programs are available for analyzing information from subjects, and computer-aided procedures have been prepared for categorizing the data given by physicians. Lifetable methods, log linear analysis, and survival regressions will be used for calculating rates and testing the significance of associations with risk factors. The main objective of the research is to provide information about the epidemiology of psychiatric disorders over time in one place of study while also comparing findings from this one place to those from other areas where similar research has been conducted.

本申请涉及一项纵向研究的扩展， 精神病学（加拿大大西洋地区的斯特林县研究）， 它将提供一个40年的患病率，发病率， 与精神疾病相关的临床结局和死亡风险 紊乱一致的数据收集程序被用于研究 1952年、1962-64年和1970年的成年人代表性样本。每个字段中 第一阶段后，采用相同的程序进行随访 对较早进入研究的个人进行调查。这些 程序包括与一个结构化的时间表， 包括抑郁症、焦虑症、身体健康和社会人口因素 沿着采访普通医生关于精神病和 相同受试者的病史。 本研究的主要目的是：（1）。选择并调查新的 1992年代表斯特林县成年人的1350名受试者样本; 2.）的情况。找到并重新采访1400名预计还活着的前受试者， 1992; 3.）收集大约950名前 可以预期已经死亡的受试者;以及4）。扩大采访 包括部分诊断面谈时间表（DIS）的方案 对于65岁及以上的人，修订的简易精神状态 考试后面增加的目的是奠定基础 将这项研究的结果与美国五个研究中心的结果进行比较 NIMH的流行病学集水区（ECA）计划，那些来自类似的 在加拿大埃德蒙顿进行的研究，以及从国家研究中得出的结果 在加拿大认知障碍的流行病学。 诊断计算机程序可用于分析来自 科目和计算机辅助程序已准备分类 医生提供的数据。寿命表方法，对数线性分析， 生存回归将用于计算率和检验 与危险因素的关联性。 这项研究的主要目的是提供有关 精神疾病的流行病学随着时间的推移在一个地方的研究， 也将这个地方的研究结果与其他地区的研究结果进行了比较， 已经进行了类似的研究。