LONGITUDINAL STUDY IN PSYCHIATRIC EPIDEMIOLOGY

精神病流行病学的纵向研究

• 批准号: 2033620
• 负责人: JANE M MURPHY
• 金额: $ 37.39万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-30 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2033620
• 关键词: Canada; aging; alcoholism /alcohol abuse; attitude; clinical anxiety; clinical depression; clinical research; disease /disorder proneness /risk; drug abuse; family genetics; gender difference; health care policy; human mortality; human subject; interview; lifestyle; longitudinal human study; mental disorder diagnosis; mental health epidemiology; organic brain syndrome; personality disorders; prognosis; relapse /recurrence; sex roles; socioeconomics

The purpose of this proposal is to build on information gathered recently as part of a longitudinal investigation of psychiatric epidemiology among adult samples of a general population. The overall objective is to provide a 40-year perspective on historical trends regarding psychiatric disorders. The site in Atlantic Canada has been given the pseudonym of "Stirling County" for protection of identity. The specific aims are to continue analysis of the accumulated body of data and to prepare a series of reports in which findings from the study will be described and, where appropriate, compared with those of recent studies. The study involves three repeated cross-sectional sample surveys (1952, 1970, and 1992) and two panel follow-up intervals (1952-1970- and 1970- 1992). Time trends will be reported regarding prevalence, incidence, clinical course, and mortality outcomes among approximately 4000 subjects. Two types of information have been gathered from the beginning of the investigation: 1.) structured interviews with subjects concerning depression, anxiety, and medical conditions.; and 2.) semi-structured interviews by psychiatrists with general physicians who have been named by subjects and asked about the medical and psychiatric histories of these subjects. The recent wave of data-gathering included administration of sections of the NIMH Diagnostic Interview Schedule and the Modified Mini-Mental Status Examination. Findings from these schedules will aid comparison to studies such as the NIMH Epidemiologic Catchment Area Program and the National Comorbidity Study, especially for common disorders such as those involving depression, anxiety, alcohol abuse, and cognitive dysfunction associated with aging. The risk factors and trends to be investigated include: birth cohort effects, aging, gender, changes in the role of women, socio-economic status, family history of psychiatric disorders, marriage and family patterns, religious/ethnic identity, and comorbidity between psychiatric and medical disorders and also within the psychiatric spectrum. The effects of health policy changes will be investigated since Canadian national health insurance was introduced into the area at the mid-point of the study interval. Analysis of data will make use of multivariate techniques such as loglinear analysis, survival regressions, and structural equation modelling. Reliability and validity of psychiatric diagnoses will be assessed.

该提案的目的是基于最近收集的信息 作为精神病学流行病学纵向调查的一部分 一般人群的成人样本。 总体目标是提供 对精神疾病历史趋势 40 年的展望。 该地点位于加拿大大西洋省份，其笔名是“斯特林” 县”以保护身份。具体目标是继续 分析积累的数据并准备一系列报告 其中将描述研究结果，并在适当的情况下， 与最近的研究相比。 该研究涉及三个重复的横断面抽样调查（1952 年， 1970 年和 1992 年）和两个小组随访间隔（1952 年-1970 年和 1970 年- 1992）。 将报告有关患病率、发生率、 大约 4000 名受试者的临床病程和死亡率结果。 从一开始就收集了两种类型的信息 调查：1.) 对有关主题的结构化访谈 抑郁、焦虑和健康状况。 2.) 半结构化 精神科医师与被任命为普通医生的访谈 受试者并询问这些人的医学和精神病史 科目。 最近的数据收集浪潮包括对以下部分的管理 NIMH 诊断面谈时间表和改良版简易精神状态 考试。 这些时间表的结果将有助于与研究进行比较 例如 NIMH 流行病学区域计划和国家 合并症研究，特别是针对常见疾病，例如涉及 抑郁、焦虑、酗酒和认知功能障碍相关 随着衰老。 要调查的危险因素和趋势包括： 出生队列 影响、老龄化、性别、妇女角色的变化、社会经济 状况、精神疾病家族史、婚姻和家庭 模式、宗教/种族身份以及精神疾病之间的共病 和医学疾病以及精神病学范围内的疾病。 这 自加拿大以来，将调查卫生政策变化的影响 国民健康保险于 2009 年中期引入该地区 学习间隔。 数据分析将利用多变量 对数线性分析、生存回归和结构分析等技术 方程建模。 精神科诊断的可靠性和有效性将 进行评估。