MUSCLE RECEPTORS
肌肉受体
基本信息
- 批准号:3393683
- 负责人:
- 金额:$ 15.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1979
- 资助国家:美国
- 起止时间:1979-01-01 至 1993-12-31
- 项目状态:已结题
- 来源:
- 关键词:afferent nerve axon biological signal transduction cats central nervous system disorders electron microscopy evoked potentials innervation mechanical stress mechanoreceptors membrane permeability membrane potentials microscopy muscle contraction muscle tension myelination myofibrils neural conduction neural information processing neural initiation neuromuscular junction neuromuscular transmission stress stretch receptors
项目摘要
This research aims to increase our understanding of sensory
transduction in somatic mechanoreceptors. Such receptors subserve
a wide variety of sensory systems which convert mechanical forces
to neural signals which are transmitted to the central nervous
system. Very little information is available on the fundamental
steps of the transduction process. We propose a study on the
primary ending of the isolated mammalian muscle spindle which is
an especially favorable preparation for a direct approach on the
problem because of: the ability to study it in isolation, the
relatively large size of the myelinated branches and their
terminals, the accessibility of structures in our isolated
decapsulated preparation and the ability to visualize its structure
microscopically. Using newly developed techniques of imaging and
patch clamping, we will investigate: 1) the conductance changes
which occur in the nerve terminals in response to mechanical stress
and the characteristics of stretch-activated channels. 2) the
spread of potentials produced by the conductance changes along the
myelinated branches of the ending and the site of impulse
initiation, and 3) a quantitative study of the structure of the
primary ending both its myelinated branches and unmyelinated
terminals, which will allow us to derive an electrical model of the
ending. This is essential for the interpretation of an
understanding of the overall transduction process in the ending.
Knowledge of the basic mechanisms of transduction may be very
important for the understanding of many disorders affecting sensory
systems.
这项研究旨在增加我们对感官的理解
体细胞机械感受器中的转导。 这些受体有助于
各种各样的感觉系统将机械力
传递到中枢神经系统的神经信号
系统 关于基本原理的信息很少
转导过程的步骤。 我们建议研究
分离的哺乳动物肌梭的初级末端,
一个特别有利的准备直接接近
问题是因为:能够孤立地研究它,
相对较大的有髓分支及其
终端,在我们的孤立结构的可访问性
去封装的制剂和可视化其结构的能力
显微镜下。 利用新开发的成像技术,
膜片钳,我们将调查:1)电导的变化
在机械应力作用下发生在神经末梢
以及牵张激活通道的特性。 2)的
由电导产生的电势的扩展沿着
末梢和冲动部位的有髓分支
引发,和3)的结构的定量研究,
初级末端它的有髓分支和无髓分支
终端,这将使我们能够得出一个电气模型的
结局 这对于解释一个
对结局中整个转导过程的理解。
对转导的基本机制的了解可能是非常重要的
对于理解许多影响感官的疾病很重要,
系统.
项目成果
期刊论文数量(0)
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