Exploitation of a novel multi-stage electrohydrodynamic device for the manufacture of therapeutic products

开发用于制造治疗产品的新型多级电流体动力装置

• 批准号: EP/J01334X/1
• 负责人: Mohan Edirisinghe
• 金额: $ 12.63万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ01334X%2F1
• 关键词: Exploitation; novel; multi; stage; electrohydrodynamic

Porous particles, fine bubbles and hollow capsules are important vehicles for effective agents for the treatment of illnesses such as cancer and their reliable and commercially successful mass production is a hot topic. This is because it directly governs the progress of medical imaging and therapeutics for advancing the frontiers of research for improved healthcare. At UCL we have invented new multi-needle, multi-stage electrically-driven devices which can operate simply using applied voltage and flow rate control. These devices, already patented and the work was awarded the 2010 Venture Prize (£25k), are robust and economical and products are made in high yield (several millions a minute). The products are also better controlled and can be made to have unique structural compartments which allow special therapeutic benefits. The work in this follow-on project will concentrate on specific products and process variables so that characterised marketable products can be made in large quantities and their manufacture exploited by putting together a business plan, marketing and licensing opportunities.

多孔颗粒、细小气泡和空心胶囊是治疗癌症等疾病的有效药物的重要载体，其可靠且商业上成功的大规模生产是一个热门话题。这是因为它直接控制着医学成像和治疗学的进展，以推进改善医疗保健的研究前沿。在UCL，我们发明了新的多针，多级电动设备，可以简单地使用施加的电压和流量控制操作。这些设备已经获得专利，并获得了2010年风险奖（2.5万英镑），坚固耐用，经济实惠，产品产量高（每分钟数百万）。这些产品还可以更好地控制，并且可以制成具有独特结构的隔室，从而获得特殊的治疗益处。这个后续项目的工作将集中在特定的产品和工艺变量上，以便能够大量生产具有特色的适销产品，并通过将商业计划，营销和许可机会放在一起来开发其制造。

项目成果

Preparation of multilayered polymeric structures using a novel four-needle coaxial electrohydrodynamic device.

• DOI: 10.1002/marc.201300777
• 发表时间: 2014-03
• 期刊: MACROMOLECULAR RAPID COMMUNICATIONS
• 影响因子: 4.6
• 作者: Labbaf, Sheyda;Ghanbar, Hanif;Stride, Eleanor;Edirisinghe, Mohan
• 通讯作者: Edirisinghe, Mohan