Creation and Exploitation of Pressurised Gyration to Manufacture Core-Sheath Structures:

加压回转过程是一种新兴的技术，它利用离心力和动态流体流动来持续地喷射出先进的功能材料，这是这项赠款申请的重点。这项技术已经显示出巨大的潜力，可以克服现有技术的局限性，制造能够安全、一致和经济有效地放大的功能材料和结构。因此，在过去的5年里，人们开发了加压回转和几种姊妹工艺(输液回转、熔体加压回转、压力耦合回转)，并将其应用于制备不同应用的功能材料。这项研究的总体动机是制造各种各样的“核心-鞘”结构，由于缺乏创新制造，这些结构在功能应用(例如医疗保健)中没有得到充分的商业开发。该项目的总体目标是开发加压回转作为一种有效制造多材料芯套结构的新方法。因此，该项目的一个非常重要的方面是在探索性实验证据的基础上开发一种加压回转技术，以产生大规模的核鞘结构。在不同浓度、不同压力和不同转速下，一种新开发的包含两个腔室的探索装置被用来在水和非水溶液中以不同的聚合物作为核和鞘成分来制备各种聚合物纳米纤维。此外，还利用该装置制备了负载纳米纤维的抗菌金属纳米颗粒。用高速相机和显微镜演示了芯鞘结构的制作。因此，本研究致力于在已有的初步器件的基础上，开发一种新的用于制造层状芯鞘结构的高成品率器件。此外，还将作出相当大的努力来分析新的程序，以便进行定量评估，以了解理论问题。它将集中在从微纳尺度上研究核鞘纤维和核壳胶囊的形成。将添加其他有机、无机和颗粒材料产生的核心-鞘结构功能化将是一个重要特征。经过处理的核心-鞘结构将使用先进的工具进行表征，以探索其独特的物理、化学和生物特性。

Pressurised gyration processes, which are the focus of this grant application is an emerging technique that utilises centrifugal force and the dynamic fluid flow to jet out advanced functional materials consistently. This technique has shown great potential in overcoming the limitations of the existing techniques to manufacture functional materials and structures that can safely, consistently and cost-effectively be up-scaled. Thus in the past 5 years pressurised gyration, and several sister-processes (infusion gyration, melt pressurised gyration, pressure-coupled infusion gyration) have been developed and applied to prepare functional materials for different applications. The overall motivation of this research is to manufacture a wide variety of "core-sheath" structures, that are not fully exploited commercially in functional applications (e.g. healthcare) simply because of lack of innovative manufacturing. The overall aim of the project is to develop pressurised gyration as a novel means of effective manufacturing of multi-material core-sheath structures. Therefore, a very significant aspect of this project is to develop a pressurised gyration technique based on exploratory experimental evidence, to generate core-sheath structures on a large scale. A newly created exploratory device containing two chambers has been used to manufacture a wide range of polymer nanofibres with different polymers in both aqueous and non-aqueous solutions as core and sheath components at various concentrations, pressures and rotating speeds. In addition antibacterial metallic nanoparticles loaded nanofibres were also produced using this device. The manufacturing of core-sheath structure has been demonstrated by using a high speed camera and microscopy. Thus, the proposed research pays attention on developing a new high yield device for manufacturing layered core-sheath structures based on our existing preliminary device. Also a considerable effort will be devoted to analyse the new process to make quantitative assessment in order to understand the theoretical issues. It will focus on investigating the forming of core-sheath fibres and core-shell capsules from micro-nanoscale. Functionalising those core-sheath structures produced with additions of other, organic, inorganic and particulate materials will be an important feature. The processed core-sheath structures will be characterised with advanced tools to explore their unique physical, chemical and biological properties.