STRUCTURE OF HUMAN POSTURE CONTROL

人体姿势控制结构

• 批准号: 3406430
• 负责人: GIN MCCOLLUM
• 金额: $ 15.33万
• 依托单位: GOOD SAMARITAN HOSP & MED CTR(PRTLND,OR)
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-03-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3406430
• 关键词: biomechanics; biophysics; body movement; hearing; muscle function; neural information processing; posture; sensorimotor system; sensory feedback; somesthesis; touch; vision

The long term goal of this research is to establish a theoretical basis for understanding sensorimotor control in posture, including behavior and its underlying physiology. A focus in the present application will be the relationship of neural activity in the cerebellum to postural control. The methods will be entirely theoretical, and a major objective of the research will be to develop a mathematical structure describing the postural control system. The work will be accomplished with the collaboration of experimental physiologists. To achieve this goal, components of strategies that reduce the number of sensorimotor control parameters will be identified, given a set of task requirements such as maintaining stability. Then the components of strategies will be represented as relations between classes of stimuli and motor commands. Since classes of stimuli can also be equivalent for a population of neurons, populations of neurons will be identified whose activity expresses the same equivalence of classes of stimuli and motor commands. Specifically, patterns of neural activity in the cerebellum will be constructed using receptive field data, in order ultimately to determine to what extent populations of active cells in the cerebellum are directly controlling posture. A mathematical structure will be developed to describe postural control at both the behavioral and the neural-activity levels. Results of this research will clarify the unified nature of postural behavior and its underlying physiology, and will provide a more rational basis for diagnosis and treatment of balance disorders.

本研究的长期目标是建立一个理论 了解姿势中的感觉运动控制的基础，包括 行为及其潜在的生理学。 当前的焦点 应用将是神经活动的关系， 小脑到姿势控制 这些方法将完全 理论上，研究的一个主要目标是 开发一个数学结构来描述姿势控制 系统 这项工作将在以下方面的合作下完成： 实验生理学家 为实现这一目标，减少贫困的战略的组成部分 将识别多个感觉运动控制参数，给定 一系列任务要求，如保持稳定。 则 战略的组成部分将被表示为 刺激和运动指令的类别。 因为刺激的种类 也可以等效于神经元群体， 神经元将被识别，其活动表达相同的 刺激和运动命令的类别的等价性。 具体来说，小脑的神经活动模式 使用感受野数据构建，以便最终 确定在多大程度上活跃的细胞群体在 小脑直接控制姿势。 数学 结构将被开发来描述姿势控制， 行为和神经活动水平。 本研究的结果将澄清的统一性质， 姿势行为及其潜在的生理学，并将提供 一个更合理的诊断和治疗的平衡基础 紊乱