MAGNETOENCEPHALOGRAPHY IN EPILEPSY

癫痫脑磁图检查

• 批准号: 3401419
• 负责人: William W. Sutherling
• 金额: $ 22.23万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3401419
• 关键词: brain disorder diagnosis; brain electrical activity; brain mapping; computer simulation; congenital oral /facial /cranial defect; direct cortical response; electrodes; evoked potentials; human subject; human tissue; magnetic field; magnetoencephalography; mathematical model; partial seizure

The Reed Neuromagnetism Laboratory with a single channel magnetometer has: (1) mapped the MEG and EEG of a human partial seizure, (2) mapped simultaneous MEG and subdural electrode of the human epileptic interictal spike, (3) used different EEG triggers to separate different spike populations in the epileptic focus, (4) modeled the MEG forward solution of a known current dipole in a human cadaver head, and (5) participated in an active collaboration with Dr. Terance M. Darcey who has modeled a moving dipole to fit both the MEG and EEG of a tangentially oriented human interictal spike mapped at UCLA. Further studies are being performed on those patients who have very frequent interictal spikes. This is anticipated to be productive but markedly limited in numbers studied and in the completeness of the information obtained. We proposed a systematic series of studies designed to extend epileptic source identification from the ideal computer model to realistic situations of interictal spikes and the seizure itself. The limitation of a single channel magnetometer prevents the natural extension of research into promising areas which have been developed at Reed and proved capable of study in the human partial seizure and in simultaneous MEG and subdural electrode monitoring. We have gone as far as we can go with 1 channel and cannot go further with our present system. A multichannel neuromagnetometer is essential to the proposed studies of the spatiotemporal structure of the MEG and EEG of the human partial seizure and of the simultaneous MEG, EEG and intracranial subdural EEG of the human interictal spike focus. In this renewal, we request the funds for a 7-channel neuromagnetometer and the salary for personnel, both essential to continue the proposed investigation of the MEG, comparison of the MEG and EEG, and integrated use of their complementary information to identify intracranial electric current sources. Funds are requested for essential consulting collaboration with Dr. Terrance Darcey at Yale University School of Medicine, New Haven, Connecticut, to model the MEG and EEG and to develop new modeling procedures to analyze the human epileptic focus. We have obtained half the funds for the neuromagnetometer from other sources and those have been completely exhausted. The funds requested here are the minimum essential to continue the research.

里德神经磁性实验室的单通道磁力计有： (1)绘制了人类部分癫痫发作的MEG和EEG，（2）绘制了 人癫痫发作间期脑磁图与硬膜下电极同步检测 （3）采用不同的脑电触发信号分离不同的锋电位 （4）模拟了癫痫灶中的MEG正解， 一个已知的电流偶极子在人的尸体头部，和（5）参与了一个 与Terance M博士的积极合作。达西曾为一个移动的 偶极子，以适应切向取向的人的MEG和EEG 在加州大学洛杉矶分校绘制的发作间期峰电位图。 正在进行进一步的研究， 那些发作间期峰电位非常频繁的患者。 这是 预计将是富有成效的，但在研究的数量和 获得的信息的完整性。 我们提出了一个系统的 一系列旨在将癫痫源识别从 理想的计算机模型，以现实情况下的发作间期尖峰， 癫痫本身。 单通道磁力计的局限性阻止了自然的 将研究扩展到已开发的有前途的领域， 里德，并证明能够在人类部分癫痫发作的研究， 同时进行脑磁图和硬膜下电极监测。 我们已经走得很远， 我们可以用一个频道，而不能用我们目前的系统进一步发展。 一 多通道神经磁力计是必不可少的拟议研究的 部分性癫痫发作脑磁图和脑电图的时空结构 和人的MEG、EEG和颅内硬膜下EEG的同步 发作间期锋电位灶 在这次更新中，我们要求资金用于 7-通道神经磁力仪和人员的工资，都是必不可少的 继续进行拟议的MEG调查，比较MEG和 脑电，并综合利用其互补信息进行识别 颅内电流源。 要求提供资金， 与耶鲁大学的Terrance Darcey博士进行咨询合作 的医学，纽黑文，康涅狄格州，建模MEG和EEG， 开发新的建模程序来分析人类癫痫病灶。 我们 神经磁力计的一半资金来自其他渠道 而那些已经完全耗尽了。 这里要求的资金是 最低限度的必要继续研究。