INPUT OUTPUT RELATIONS IN VOLUNTARY MOVEMENT

随意运动的输入输出关系

• 批准号: 3399201
• 负责人: CLAUDE P GHEZ
• 金额: $ 13.65万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3399201
• 关键词: brain mapping; cerebellum; conduction anesthesia; electromyography; electrophysiology; head movements; limb movement; motor cortex; neural information processing; neuromuscular function; proprioception /kinesthesia; psychomotor reaction time; psychomotor tracking; reticular formation; reticulospinal tract; rubrospinal tract; sensorimotor system; sensory cortex; sensory feedback; single cell analysis; spinal cord mapping

The proposed experiments investigate the neural mechanisms of rapid targeted responses of the limb and neck in the cat. Three groups of experiments are planned and are based on results obtained in the current period. First, we will ascertain the neural pathways that are responsible for transferring information from the target to the brain structures responsible for specifying trajectory parameters. This will be achieved by determining deficits in performance of a tracking task after reversible inactivation of several candidate pathways by injection of local anesthetics and other agents which block conduction or transmission of neural impulses. The primary question is to ascertain whether the processing of target information is mediated by the sensory cortical area or whether subcortical processing suffices. Each animal will serve as its own control and deficits produced by inactivation of different pathways will be compared in the same animal. Second, we will also define the changes in the preparation and execution of targeted responses following selective inactivation of two subregions of the motor cortex. [This part of the study, seeks to determine whether predictions deriving from our recent anatomical and physiological studies can be corroborated.] This experiment seeks principally to determine whether the prediction that the only rostral subregion of the arm area is concerned with response initiation. The third goal of the proposed work is to define the contributions of reticulospinal and other reticular neurons in the initiation and control of targeted neck and arm responses. Through single neuron recordings in the behaving animal we hope to ascertain the role of this neuronal system in the execution of the behaviors.

所提出的实验研究了快速反应的神经机制 猫的四肢和颈部的有针对性的反应。 三组 计划进行实验并基于当前获得的结果 时期。 首先，我们将确定负责的神经通路 用于将信息从目标传输到大脑结构 负责指定轨迹参数。 这将通过以下方式实现 确定可逆后跟踪任务的性能缺陷 通过注射局部注射剂灭活几个候选途径 麻醉剂和其他阻断传导或传播的药物 神经冲动。 首要问题是确定是否 目标信息的处理由感觉皮层区域介导 或者皮层下处理是否足够。 每只动物都将作为其 自身控制和不同途径失活产生的缺陷 将在同一动物中进行比较。 其次，我们还将定义 以下是有针对性的应对措施的准备和执行方面的变化 运动皮层两个子区域的选择性失活。 [这部分 该研究的目的是确定预测是否来自我们的 最近的解剖学和生理学研究可以证实。]这 实验主要是为了确定预测是否 只有手臂区域的头侧分区与反应有关 引发。 拟议工作的第三个目标是定义 网状脊髓和其他网状神经元的贡献 启动和控制目标颈部和手臂反应。 通过单 我们希望通过对行为动物的神经元记录来确定其作用 这个神经系统在执行行为。