INPUT OUTPUT RELATIONS IN VOLUNTARY MOVEMENT

拟议的实验研究了快速刺激的神经机制。 猫四肢和颈部的定向反应。三组 实验是有计划的，并且是基于在当前 句号。首先，我们将确定负责的神经通路 用于将信息从目标传输到大脑结构 负责指定弹道参数。这将通过以下方式实现 在可逆后确定跟踪任务的性能缺陷 局部注射灭活几条候选通路 麻醉剂和其他阻断传导或传递的药物 神经冲动。主要的问题是要确定 目标信息的处理是由感觉皮层区域调节的 或者皮层下处理是否足够。每只动物都将作为它的 自身控制和因不同途径失活而产生的缺陷 将在同一只动物身上进行比较。其次，我们还将定义 以下是有针对性的答复的编制和执行方面的变化 运动皮质两个亚区的选择性失活。[本部 试图确定从我们的研究中得出的预测 最近的解剖学和生理学研究可以得到证实。]这 实验的主要目的是确定这一预测是否 只有上臂区域的吻侧区域才与反应有关 入会仪式。拟议工作的第三个目标是定义 脊髓网状细胞和其他网状神经元在脑内的作用 启动和控制有针对性的颈部和手臂反应。通过单次 我们希望确定行为动物的神经元记录所起的作用 这种神经系统在执行行为。

The proposed experiments investigate the neural mechanisms of rapid targeted responses of the limb and neck in the cat. Three groups of experiments are planned and are based on results obtained in the current period. First, we will ascertain the neural pathways that are responsible for transferring information from the target to the brain structures responsible for specifying trajectory parameters. This will be achieved by determining deficits in performance of a tracking task after reversible inactivation of several candidate pathways by injection of local anesthetics and other agents which block conduction or transmission of neural impulses. The primary question is to ascertain whether the processing of target information is mediated by the sensory cortical area or whether subcortical processing suffices. Each animal will serve as its own control and deficits produced by inactivation of different pathways will be compared in the same animal. Second, we will also define the changes in the preparation and execution of targeted responses following selective inactivation of two subregions of the motor cortex. [This part of the study, seeks to determine whether predictions deriving from our recent anatomical and physiological studies can be corroborated.] This experiment seeks principally to determine whether the prediction that the only rostral subregion of the arm area is concerned with response initiation. The third goal of the proposed work is to define the contributions of reticulospinal and other reticular neurons in the initiation and control of targeted neck and arm responses. Through single neuron recordings in the behaving animal we hope to ascertain the role of this neuronal system in the execution of the behaviors.