TRAJECTORY SPECIFICATION IN TARGETED LIMB MOVEMENT

该提案调查了准确生产的机制， 肢体的运动和力量的变化指向一个目标。 四组 的实验计划，并探讨来自试点数据的假设。 首先，我们将确定留下的轨迹的特征， 当反应指向不同距离的目标时不变。 试点数据表明，这种反应在持续时间和 只控制振幅。 我们现在将探讨这一点的普遍性 控制策略，确定它是如何影响的变化， 条件、负载、精度和环境。 第二，我们将确定 控制政策已经实施。 试点数据与以下观点一致， 通过利用激动剂的推拉机制实现控制， 拮抗剂 该拮抗剂被提议用于线性化 周边植物的特性。 每一个的机械贡献 将被确定。 三是探索中央机制 负责指定响应方向和幅度通过一个新的 范例 试点数据表明目标刺激由两个人处理 独立频道。 一个似乎会触发一个符合 预先计算的估计。 第二个更新了这一估计从刺激 信息. 第四，小脑的功能缺陷 将分析辨距障碍以确定缩放的异常， 更新和更正。

The proposal investigates the mechanisms underlying the accurate production of limb movements and force changes directed towards a target. Four groups of experiments are planned and explore hypotheses derived from pilot data. First, we will determine the features of trajectories which remain invariant when responses are directed to targets at different distances. Pilot data suggests that such responses are regulated in duration and controlled only in amplitude. We will now explore the generality of this control policy by determining how it is affected by changes in initial conditions, loads, accuracy and context. Second, we will determine how the control policy is implemented. Pilot data is compatible with the view that control is achieved through a push-pull mechanism utilizing agonist and antagonist. The antagonist is proposed to be used to linearize the properties of the peripheral plant. The mechanical contributions of each will be determined. Third, we will explore the central mechanisms responsible for specifying response direction and amplitude through a new paradigm. Pilot data indicates that target stimuli is processed by two independent channels. One appears to trigger a response conforming to a pre-computed estimate. The second updates this estimate from stimulus information. Fourth, the functional deficits underlying cerebellar dysmetria will be analyzed to ascertain the abnormalities in scaling, updating and correction.