SPATIAL FIRING PROPERTIES OF HIPPOCAMPAL NEURONS

海马神经元的空间放电特性

• 批准号: 3401231
• 负责人: JOHN L KUBIE
• 金额: $ 7.1万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3401231
• 关键词: electroencephalography; histology; interneurons; neural information processing; neurophysiology; neuropsychology; open field behavior; orientation; space perception; stimulus /response; telemetry

There are neurons in the hippocampus of rats (and other mammals) that have the remarkable property of location-specific firing. A given 'place' cell will fire only when the rat is in a circumscribed part of its current environment, largely independent of what the rat is doing there. The properties of place cells will be thoroughly investigated by recording single neurons in freely-moving rats and using a quantified, computer-operated data collection system. Our immediate goals are to: 1) Investigate the extent to which the geometry of an anvironment controls the firing of place cells. 2) Investigate the extent to which the specific stimuli within an environment control the firing of spatial cells. 3) Determine the spatally-specific firing properties of other anatomically and physiologically identifiable cell types. 4) Attempt to explain differences in spatial firing among hippocampal cell types on the basis of known anatomy and synaptic connectivity. 5) Measure temporal and spatial relationships for the firing of pairs of neighboring hippocampal cells. These data will help us achieve goal 4. 6) Find ways of modifying spatially-specific firing manipulating the geometry and contents of recording environments. Our long-term goal is to understand how the properties of physical space are represented in the neural space of the hippocampus.

在大鼠(和其他哺乳动物)的海马区有神经元 特定位置射击的显著特性。给定的“位置”单元格 只有当老鼠处于其电流的限定部分时才会开火 环境，在很大程度上与老鼠在那里做什么无关。这个 将通过记录来彻底调查放置单元的属性 在自由活动的大鼠中使用量化的、 计算机操作的数据收集系统。 我们的近期目标是： 1)调查环境的几何图形控制的程度 Place细胞的激发。 2)调查特定刺激在多大程度上 环境控制着空间细胞的放电。 3)确定其他解剖学上的斑块特有的激发特性 以及生理上可识别的细胞类型。 4)试图解释海马神经元在空间放电上的差异 根据已知的解剖学和突触连通性进行分类。 5)测量成对发射的时间和空间关系 邻近的海马区细胞。这些数据将帮助我们实现目标4。 6)找到修改空间特定射击的方法，操纵 记录环境的几何形状和内容。 我们的长期目标是理解物理空间的属性 出现在海马体的神经空间中。