SPATIAL FIRING PROPERTIES OF HIPPOCAMPAL NEURONS

在老鼠（和其他哺乳动物）的海马体中有神经元， 特定位置发射的显著特性。 一个给定的“位置”单元格 只有当老鼠处于电流的限定部分时， 环境，很大程度上独立于老鼠在那里做什么。 的 位置细胞的性质将通过记录 在自由移动的大鼠中的单个神经元， 计算机操作的数据收集系统。 我们的近期目标是： 1)调查建筑物的几何形状控制的程度 定位细胞的放电 2)调查特定刺激在多大程度上 环境控制空间细胞的放电。 3)确定其他解剖结构的特定击发特性 和生理上可识别的细胞类型。 4)海马神经元空间放电差异的解释 类型的基础上已知的解剖和突触连接。 5)测量时间和空间的关系，为发射对 邻近的海马细胞 这些数据将帮助我们实现目标4。 6)找到修改空间特定发射的方法， 记录环境的几何形状和内容。 我们的长期目标是了解物理空间的性质 在海马体的神经空间中表现出来。

There are neurons in the hippocampus of rats (and other mammals) that have the remarkable property of location-specific firing. A given 'place' cell will fire only when the rat is in a circumscribed part of its current environment, largely independent of what the rat is doing there. The properties of place cells will be thoroughly investigated by recording single neurons in freely-moving rats and using a quantified, computer-operated data collection system. Our immediate goals are to: 1) Investigate the extent to which the geometry of an anvironment controls the firing of place cells. 2) Investigate the extent to which the specific stimuli within an environment control the firing of spatial cells. 3) Determine the spatally-specific firing properties of other anatomically and physiologically identifiable cell types. 4) Attempt to explain differences in spatial firing among hippocampal cell types on the basis of known anatomy and synaptic connectivity. 5) Measure temporal and spatial relationships for the firing of pairs of neighboring hippocampal cells. These data will help us achieve goal 4. 6) Find ways of modifying spatially-specific firing manipulating the geometry and contents of recording environments. Our long-term goal is to understand how the properties of physical space are represented in the neural space of the hippocampus.