DOPAMINERGIC NEURONS: CELL INTERACTIONS AND PLASTICITY

多巴胺能神经元：细胞相互作用和可塑性

• 批准号: 3399804
• 负责人: CHRISTINE B JAEGER
• 金额: $ 7.91万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-08-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3399804
• 关键词: cell aggregation; cell cell interaction; central nervous system; electron microscopy; graft versus host disease; histochemistry /cytochemistry; immunochemistry; microscopy; nervous system transplantation; neural information processing; neural plasticity; neuroanatomy; newborn animals; parasympathetic nervous system; substantia nigra; sympathetic nervous system; synapses

Alterations in longevity of specific neurons may bring about severe behavioral deficits of a mature organism. The investigations proposed here will study the question of whether changes in position and cellular interactions will affect survival of dopaminergic neurons. Immunocytochemical and histochemical approaches are to be used to identify dopaminergic and putative cholinergic neurons. Experimental perturbation of the dopaminergic neuron systems will be carried out by neonatal lesions and transplantation techniques. Developing mesencephalic dopaminergic neurons will be partially deafferented in situ or transplanted to various regions of the brain of newborn rats. Initally these studies will test the influence of variable environmental conditions (e.g. different host brain areas, differences in the types of afferent fibers) on the connection plasticity of dopaminergic neurons and their effect on longevity of such neurons. Qualitative and quantitative analysis will be carried out at light and electron microscopic levels. Following the above procedures, the effect of cell interactins between dopaminergic neurons and putative cholinergic cells (striatal, tectal) will be investigated in co-grafts and reaggregation grafts. Since synapses are the morphological entities that signify neuron interactions, particular emphasis is placed on observations at the fine structural level.

特定神经元寿命的改变可能会带来严重的后果

项目成果

Aromatic L-amino acid decarboxylase in the rat brain: immunocytochemical localization during prenatal development.

大鼠脑中的芳香族 L-氨基酸脱羧酶：产前发育期间的免疫细胞化学定位。

• DOI: 10.1016/0306-4522(86)90183-1
• 发表时间: 1986
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Jaeger,CB

Morphological and immunocytochemical characteristics of PC12 cell grafts in rat brain.

大鼠脑中 PC12 细胞移植物的形态学和免疫细胞化学特征。

• DOI: 10.1111/j.1749-6632.1987.tb23684.x
• 发表时间: 1987
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Jaeger,CB

Axon terminal clustering in nigrostriatal double grafts.

黑质纹状体双移植物中的轴突末端聚集。

• DOI: 10.1016/0165-3806(86)90202-6
• 发表时间: 1986
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Jaeger,CB

Immunocytochemical study of PC12 cells grafted to the brain of immature rats.

移植到未成熟大鼠大脑中的 PC12 细胞的免疫细胞化学研究。

• DOI: 10.1007/bf00261353
• 发表时间: 1985
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Jaeger,CB

Cytoarchitectonics of substantia nigra grafts: a light and electron microscopic study of immunocytochemically identified dopaminergic neurons and fibrous astrocytes.

黑质移植物的细胞结构：免疫细胞化学鉴定的多巴胺能神经元和纤维星形胶质细胞的光学和电子显微镜研究。

• DOI: 10.1002/cne.902310110
• 发表时间: 1985
• 期刊: The Journal of comparative neurology
• 作者: Jaeger,CB