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High-speed multi-channel 3-D Optical Coherence Tomography studies of the biomechanics of skin friction.

皮肤摩擦生物力学的高速多通道 3D 光学相干断层扫描研究。

基本信息

批准号：
EP/K009699/1
负责人：
Stephen Matcher
金额：
$ 83.18万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK009699%2F1
关键词：
speed multi channel Optical Coherence

项目摘要

The health of the skin has profound effects on both our physical and psychological well-being. Enormous academic and commercial effort is devoted to optimising the health and appearance of skin. The barrier function of skin has been widely studied, but less well studied is its role in providing enough friction to allow us to grip and manipulate objects. Excessive friction can produce undesirable skin conditions such as chaffing and irritation in many scenarios such as wearing a respiration face mask or the skin being in contact with a damp surface. Conversely reduction of skin friction can occur in old age and compound the difficulties experienced by the older population when gripping and manipulating objects.Many potential determinants of friction have been studied, including applied load, skin deformation, skin mechanical properties and surface textures and materials, but the sub-surface behaviour and skin strain has not been investigated as rigorously. Most of these parameters have been investigated statically and although it is known that they will change when the contact is dynamic no quantitative data is available for using in computer models of skin.The aim in this work will be to develop new imaging techniques to allow sub-surface observation of how skin behaves when it is sliding against an object and what influences this the most, for example, skin moisture, applied load, sliding speed etc. The contact area between skin and object will also studied in greater detail than before as this has a major effect on friction and as yet no techniques exist for characterising this in a moving contact.The objectives of the work will initially focus on developing the equipment and techniques needed to observe the surface and sub-surface behaviour. These will then be combined with skin testing apparatus to allow the measurements of friction etc. to be taken in parallel with the sub-surface images.The information from the tests and the techniques themselves will then be applied in three practical case studies to ensure real world impact for the work. The first will involve working with Philips on studying facial masks used by sleep apnea sufferers. Test data will help improve computer models of the contact between facial skin and a mask. The second will be carried out with Unilever and focus on characterising the effects of skin creams and cleansers. The final case study will be on using the new non-invasive imaging technique in clinical studies carried out by dermatologists at The University of Sheffield to replace tape-stripping methods currently used to study skin damage.

皮肤的健康对我们的身体和心理健康都有深远的影响。大量的学术和商业努力致力于优化皮肤的健康和外观。皮肤的屏障功能已经得到了广泛的研究，但较少研究的是它在提供足够的摩擦力以使我们能够抓握和操纵物体方面的作用。过度摩擦会产生不期望的皮肤状况，例如在许多情况下的擦伤和刺激，例如佩戴呼吸面罩或皮肤与潮湿表面接触。相反，皮肤摩擦力的减少可能发生在老年人，并加剧了老年人在抓握和操纵物体时所经历的困难。许多潜在的摩擦力决定因素已经被研究，包括施加的载荷，皮肤变形，皮肤机械性能和表面纹理和材料，但表面下的行为和皮肤应变还没有被严格调查。这些参数中的大多数都是静态研究的，尽管众所周知，当接触是动态的时，它们会发生变化，但没有定量数据可用于皮肤的计算机模型。这项工作的目的是开发新的成像技术，以允许亚表面观察皮肤在相对于物体滑动时的行为以及影响最大的因素，例如皮肤湿度、施加的负载、滑动速度等。皮肤和物体之间的接触面积也将比以前更详细地研究，因为这对摩擦力有重大影响，而且目前还没有技术来表征移动接触中的摩擦力。这项工作的目标最初将集中在开发观察表面和次表面行为所需的设备和技术上。这些技术将与皮肤测试仪器相结合，以便在获得表面下图像的同时测量摩擦力等。然后，将测试和技术本身的信息应用于三个实际案例研究，以确保工作产生真实的世界影响。第一个项目将涉及与飞利浦合作研究睡眠呼吸暂停患者使用的面膜。测试数据将有助于改善面部皮肤和面具之间接触的计算机模型。第二个项目将与联合利华合作，重点是描述护肤霜和清洁剂的效果。最后的案例研究将是在谢菲尔德大学皮肤科医生进行的临床研究中使用新的非侵入性成像技术，以取代目前用于研究皮肤损伤的胶带剥离方法。