HIPPOCAMPAL COMMISSURE FUNCTION AND ANATOMY

许多当代的工作集中在海马体作为一种结构 对记忆的独特重要性。因此，显然对……感兴趣 通过以下方式了解哪些信息从一个半球传递到另一个半球 海马区连合途径(HC)。考查这个问题， 然而，到目前为止，一直被认为是不可接近的，因为 背侧HC(DHC)与上覆痂体部(CC)的粘连 以及对纤维连通性的了解不足 构成DHC和CC的毗连部分。这种不切实际 现在松了一口气，因为对相关的 提出一种新的手术策略的大脑半球间通路被设计出来 并在这个实验室里对猕猴进行了测试，这将允许测试 跨DHC的视觉/助记信息的半球间传递 单独或与CC压部结合。这个 DHC-钚的结合已经在这方面得到了广泛的研究。 然而，完全不知道DHC是否分享， 复制或增强压痕的能力，或者，实际上， 它是否解释了以前归因于 后者。视觉辨别向单侧大脑半球的迁移 学习到的另一个和大脑半球之间的认知之前 将对呈现的视觉图像进行测试；在相同的动物身上， 构成DHC的纤维的复杂来源和目的地， 压部和前连合-所有这些都有成分产生 共同来自海马区旁回-将被检查。结果是 应该促进对半球间过程及其相互作用的理解 与记忆的关系。此外，由于大脑半球间的加工一直是 在精神分裂症中被证明是异常的，结果将有助于 基本信息与理解一些 这种复杂精神障碍的症状。

Much contemporary work focuses on the hippocampus as a structure of unique importance for memory. It is thus of obvious interest to understand what information passes from one hemisphere to the other by way of the hippocampal commissure (HC). Examination of this question, however, has heretofore been deemed unapproachable because of the close adherence of the dorsal HC (dHC) to the overlying corpus callosum (CC) and insufficient knowledge about the connectivities of the fibers that constitute the dHC and contiguous parts of the CC. This impracticality is now relieved by emerging understanding of the relevant interhemispheric pathways, which suggest a new surgical strategy, devised and tested in this laboratory on macaques, that will permit testing interhemispheric transfer of visual/mnemonic information across the dHC in isolation, or in conjunction with the splenium of the CC. The dHC-splenium combination has already been extensively studied in this regard; however, it is entirely unknown whether the dHC shares, duplicates, or augments the capabilities of the splenium or, indeed, whether it accounts for some of the properties previously attributed to the latter. The transfer to one hemisphere of visual discriminations learned by the other and interhemispheric recognition of previously presented visual images will be tested; and, in the same animals, the complex origin and destination of fibers that constitute the dHC, splenium, and anterior commissure-all of which have components arising in common from the parahippocampal gyrus-will be examined. The results should advance understanding of interhemispheric processes and their relation to memory. Moreover, since interhemispheric processing has been shown to be abnormal in schizophrenia, the results will contribute fundamental information pertinent to understanding of some of the symptoms of this complex mental disorder.