Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities

用于递送 siRNA 的聚合物纳米颗粒：机制和机遇

• 批准号: LP160100705
• 负责人: Prof Colin Pouton
• 金额: $ 35.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-11-22 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100705
• 关键词: Polymeric; nanoparticles; delivery; siRNA; mechanisms

Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities. This project aims to improve the delivery of small interfering RNA (siRNA) molecules using self-assembling nanoparticles. A series of biological barriers, at tissue and intracellular levels, limit the distribution of siRNA, and prevent these macromolecules from fulfilling their potential as therapeutic agents. Limited penetration of tissues restricts access to target cells, and intracellular enzymes often degrade the small proportion of the dose that is taken up by cells. The project intends to investigate new mechanisms to overcome these biological barriers using novel chemical approaches. This research is expected to have major health and economic outcomes, nationally and internationally.

用于递送siRNA的聚合纳米颗粒：机制和机会。该项目旨在利用自组装纳米颗粒改善小干扰RNA （siRNA）分子的递送。在组织和细胞内水平的一系列生物屏障限制了siRNA的分布，并阻止这些大分子发挥其作为治疗剂的潜力。组织的有限渗透限制了进入目标细胞，细胞内酶通常会降解细胞吸收的一小部分剂量。该项目旨在研究利用新的化学方法克服这些生物屏障的新机制。预计这项研究将在国内和国际上产生重大的健康和经济成果。