Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities

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Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities. This project aims to improve the delivery of small interfering RNA (siRNA) molecules using self-assembling nanoparticles. A series of biological barriers, at tissue and intracellular levels, limit the distribution of siRNA, and prevent these macromolecules from fulfilling their potential as therapeutic agents. Limited penetration of tissues restricts access to target cells, and intracellular enzymes often degrade the small proportion of the dose that is taken up by cells. The project intends to investigate new mechanisms to overcome these biological barriers using novel chemical approaches. This research is expected to have major health and economic outcomes, nationally and internationally.