Physiologically-based pharmacokinetics and pharmacodynamics of therapeutic stem cells for liver disease

基于生理学的干细胞治疗肝病的药代动力学和药效学

• 批准号: nhmrc : 1126091
• 负责人: Prof Colin Pouton
• 金额: $ 57.98万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiologically-based-pharmacokinetics-liver-disease/947728
• 关键词: Physiologically; based; pharmacokinetics; pharmacodynamics; therapeutic

This project focuses on the challenging area of effective and optimal dosing cell-based therapy for liver diseases. We will investigate the fate and therapeutic effects of natural, modified and artificial therapeutic cells in the body and in liver regions using a physiologically-based kinetic model. Our key goal is advance cell therapy by providing a better understanding and dosing guidelines.

该项目的重点是有效和最佳剂量的基于细胞的肝病治疗的挑战性领域。我们将使用基于生理学的动力学模型研究天然，修饰和人工治疗细胞在体内和肝脏区域的命运和治疗效果。我们的主要目标是通过提供更好的理解和剂量指南来推进细胞治疗。