Fine control of nucleic acid transport using cyclic peptide nanotubes

使用环肽纳米管精细控制核酸运输

• 批准号: DP180103661
• 负责人: Prof Colin Pouton
• 金额: $ 35.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103661
• 关键词: Fine; control; nucleic; acid; transport

This project aims to develop new technology to enhance the transport of nucleic acids (DNA or RNA) across biological membranes, and to facilitate the delivery of nucleic acids into mammalian cells. Elaborate transport mechanisms have emerged by evolution of viruses but the use of viruses for therapeutic purposes presents safety challenges. This project aims to enhance the efficiency of synthetic nucleic acid delivery systems, making use of novel biocompatible materials which assemble into controlled three-dimensional structures, offering more control over membrane interactions. The project is expected to provide a new platform of smart materials which could be developed for biomedical applications in the future.

该项目旨在开发新技术，以增强核酸（DNA或RNA）穿过生物膜的运输，并促进核酸进入哺乳动物细胞。 通过病毒的进化已经出现了复杂的转运机制，但是将病毒用于治疗目的提出了安全性挑战。 该项目旨在提高合成核酸递送系统的效率，利用新型生物相容性材料组装成受控的三维结构，提供对膜相互作用的更多控制。该项目有望为未来的生物医学应用提供一个新的智能材料平台。