Fine control of nucleic acid transport using cyclic peptide nanotubes

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This project aims to develop new technology to enhance the transport of nucleic acids (DNA or RNA) across biological membranes, and to facilitate the delivery of nucleic acids into mammalian cells. Elaborate transport mechanisms have emerged by evolution of viruses but the use of viruses for therapeutic purposes presents safety challenges. This project aims to enhance the efficiency of synthetic nucleic acid delivery systems, making use of novel biocompatible materials which assemble into controlled three-dimensional structures, offering more control over membrane interactions. The project is expected to provide a new platform of smart materials which could be developed for biomedical applications in the future.