CONFERENCE ON WOUND REPAIR AND FIBROBLASTS

生长因子、生长因子分子生物学研究进展 受体，以及细胞/基质受体，以及对这些 蛋白质对细胞功能具有上下文和组合效应 使得调查人员能够就伤口如何形成相当详细的假设 修复过程可能会进化和倒退。最近推出的 对这些蛋白质及其效应器功能的探测已经给出了 用于检验这些假说和搜索这些假说的调查工具 失调的修复可能导致无法愈合的伤口或 纤维性疾病。逐渐地，调制细胞的外部信号 组织修复中的表型及其细胞内调控 表型调控将被阐明。通过吸引调查人员 来自不同领域的人一起，希望这次会议将加快 我们对伤口修复的理解，从而有助于 对无法愈合的伤口和纤维性疾病的干预。

Advancements in the molecular biology of growth factors, growth factor receptors, and cell/matrix receptors and the appreciation that these proteins have contextual and combinational effects on cell function have allowed investigators to form rather elaborate hypotheses as to how wound repair processes may evolve and regress. The recent availability of probes for these proteins and their effector functions has given the investigator tools with which to test these hypotheses and to search for mechanisms by which dysregulated repair may lead to nonhealing wounds or fibrotic disease. Gradually the external signals that modulate cell phenotype during tissue repair and the intracellular controls of this phenotypic modulation will become elucidated. By drawing investigators together from diverse fields, it is hoped that this meeting will speed our understanding of wound repair and thereby facilitate beneficial intervention in nonhealing wounds and fibrotic disease.