JOINT CONFERENCE ON MUSCLE AND CARDIOVASCULAR BIOLOGY

一个调控基因矩阵的鉴定和分离 致力于骨骼肌生成是一项关键的突破 脊椎动物生物学开始为更普遍的 对哺乳动物细胞决定和调控过程的理解 分化的稳定性。每个成员的职能和相关性 这个调控基因家族在体外和体内的肌肉发生过程中仍然存在 应得到澄清，并应提供一个进行实质性辩论的论坛，因为 这些发现激起了相当大的兴趣，吸引了许多人 研究人员到现场。会议将讨论的主要问题 重点是： 1.细胞历史、同源异型盒基因和模式的相关性 中胚层前体细胞发育过程中的形成 测定成肌细胞。 2.细胞和分子生物学对肌源性疾病的承诺 血统。 3.收缩蛋白基因的组织和阶段特异性调控 表情。 4.突触发生的分子生物学。 5.神经肌肉疾病的分子发病机制。

Identification and isolation of a matrix of regulatory genes governing commitment to skeletal myogenesis represents a pivotal breakthrough in vertebrate biology that is beginning to open the door to a more general understanding of the processes governing mammalian cell determination and stability of differentiation. The function and relevance of each member of this regulatory gene family to in vitro and in vivo myogenesis remains to be elucidated and should provide a forum for substantial debate since the findings have stimulated considerable interest and attracted many researchers to the field. The major problems on which the meeting will focus are: 1. The relevance of cell history, homeobox genes and pattern formation in the developmental progression from mesodermal precursor to determine myoblast. 2. The cell and molecular biology of commitment to the myogenic lineage. 3. Tissue and stage specific regulation of contractile protein gene expression. 4. The molecular biology of synaptogenesis. 5. The molecular pathogenesis of neuromuscular disease.