CONFERANCE ON REGULATION OF TRANSCRIPTION ELONG AND TERM

1991年应该是举行一次关于机制问题的大规模会议的好时机 转录延伸和终止的过程 原核生物和真核生物系统的研究人员。 已经存在 原核生物在这一课题上的大背景研究。 但这 数据目前正在进行重大的重新评估，新的模型正在 正在浮现 真核生物的研究不那么先进，但意义重大， 几乎每月都有意外结果的报告。 在各领域中， 目前感兴趣的如下：1）通过RNA聚合酶I终止， 线粒体聚合酶，可能还有一些聚合酶II基因， 一种位点特异性DNA结合蛋白的意外作用， 新机制 也有报道聚合酶III可以利用一种 小的核RNP以促进转录物的终止/释放。 （二） 一些重要的原癌基因（myc和myb），以及某些病毒 基因（艾滋病病毒）利用停顿和终止来调节基因 表情 3)mRNA 3'加工位点（polyA添加）具有一个 对终止位点选择和mRNA稳定性有很强的影响， 机制尚不清楚。 相反，在某些情况下， 终结者本身似乎也作为一个组成部分， 起始位点 所有这些领域都在积极调查之中， 会是一场激动人心的会议

1991 should be a good time to hold a large-scale conference on mechanisms of transcription elongation and termination that would bring together researchers in both prokaryote and eukaryote systems. There already exists a large background of research in prokaryotes on this topic. However, this data is currently undergoing significant re-evaluation and new models are emerging. Research in eukaryotes is less advanced but significant and unexpected results are being reported almost monthly. Among areas of current interest are the following: 1) Termination by RNA polymerase I, mitochondrial polymerase, and possibly some polymerase II genes involves the unexpected action of a site-specific DNA binding protein, a relatively novel mechanism. Also there are reports that polymerase III may utilize a small nuclear RNP to facilitate termination/release of the transcript. 2) Several important proto-oncogenes (myc and myb), as well as certain viral genes (AIDS virus) utilize pausing and termination to regulate gene expression. 3) The site of mRNA 3' processing (polyA addition) has a strong effect on termination site selection and mRNA stability via mechanisms that are yet unknown. Conversely, there are instances where the terminator itself appears to also function as an integral component of the initiation site. All of these areas are under active investigation and will make for an exciting meeting.