CONFERENCE ON THE ADIPOSE CELL: MODEL OF HORMONE ACTION

最近认识到，禽逆转录病毒v- erbA编码甲状腺激素受体，是超家族成员 调控基因的研究开辟了许多新的研究领域。 的 研究发现至少有2个基因和3个mRNA编码甲状腺激素 受体和2个mRNA产生的这些基因，不编码 甲状腺结合蛋白提出了具有挑战性的功能问题。 目前正在努力确定激素特异性的基础， 受体与其他核蛋白的相互作用以及顺式作用 靶基因区域，以及甲状腺激素 调节基因表达。 这些发展也提供了工具， 来解决重要的生理问题。 因此，有可能 确定作为甲状腺激素直接靶点的特定基因， 在分子水平上追踪导致被识别的 激素的代谢和形态发生作用。 的目的 会议是正在进行的研究的快速传播， 希望相互关联的数据能够浮出水面，从而产生新的概念， 和富有成效的调查路线。

The recent recognition that cellular homologs of the avian retrovirus v- erbA code for thyroid hormone receptors and are members of a superfamily of regulatory genes has opened many new areas of investigation. The findings are at least 2 genes and 3 mRNA's coding for thyroid hormone receptors and 2 mRNAs arising from these genes which do not code for thyroid binding proteins has posed challenging functional questions. Efforts are under way to define the basis of hormonal specificity, the interaction of the receptors with other nuclear proteins and cis-acting regions of target genes, and the mechanism by which thyroid hormone regulates gene expression. These developments have also presented tools for solving important physiological questions. Thus, it may be possible to identify specific genes as direct thyroid hormone targets and to trace at the molecular level the circuits which lead to the recognized metabolic and morphogenic effects of the hormone. The objective of the conference is the rapid dissemination of the ongoing research in the hope that interlocking data will surface which will lead to new concepts and productive lines of investigation.