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CONFERENCE ON PROTEIN FOLDING AND DESIGN

CONFERENCE ON PROTEIN FOLDING AND DESIGN
蛋白质折叠和设计会议
批准号:
3435122
负责人:
CHARLES Frederick FOX
金额:
$0.3万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-03-15 至 1992-02-29

项目摘要

项目成果

CHARLES Frederick FOX的其他基金

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中文摘要
翻译
蛋白质如何折叠成其独特的三维结构?多么 蛋白质的三维结构会产生功能吗? 蛋白质能被设计吗,无论是从第一原理还是通过 天然蛋白质亚结构的重建?可以低分子量 并设计出高度稳定的天然蛋白质模拟物?这次会议 将描述在理解这些问题方面的进展 现代分子生物学的核心。最近几年的折叠主题 已经在各种基因调节蛋白中被识别,并且它们的 结构正通过预测方法的组合来确定, 核磁共振和结晶学。折叠问题取得了相当大的进展 已经在体外和整个细胞中进行了研究。巨大的进步 已经在理解膜的结构和功能方面取得了进展 蛋白质。我们已经开始研究和操纵的曲目 免疫球蛋白及其相关的生物分子识别 分子。这次会议应该把化学家、分子 生物学家和细胞生物学家回顾了这些方面的最新进展 并讨论这一多学科领域的未来。
英文摘要
How do proteins fold into their unique three-dimensional structures? How does the three dimensional structure of a protein give rise to function? Can proteins be designed, either from first principles or through reconstruction of natural protein substructures? Can low molecular weight and highly stable mimics of natural proteins be designed? This meeting will describe progress towards understanding these questions that lie at the heart of modern molecular biology. In-recent years folding motifs have been recognized in a variety of gene regulatory proteins, and their structures are being determined by a combination of predictive methods, NMR, and crystallography. Considerable progress with the folding problem has been made in vitro studies as well as whole cells. Enormous progress has been made in understanding the structures and functions of membrane proteins. We have begun to study and manipulate the repertoire of biological molecular recognition using immunoglobulins and related molecules. This meeting should bring together chemists, molecular biologists, and cellular biologists to review recent advances in these areas, and discuss the future of this multidisciplinary field.
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CONFERENCE ON WOUND REPAIR AND FIBROBLASTS
  • 批准号:
    3433766
  • 项目类别:
  • 资助金额:
    $1.0万
  • 财政年份:
    1991
  • 负责人:
    CHARLES Frederick FOX
  • 依托单位:
CONFERENCE ON GROWTH FACTOR SIGNAL TRANSDUCTION
  • 批准号:
    3434185
  • 项目类别:
  • 资助金额:
    $0.2万
  • 财政年份:
    1991
  • 负责人:
    CHARLES Frederick FOX
  • 依托单位:
CONFERANCE ON REGULATION OF TRANSCRIPTION ELONG AND TERM
  • 批准号:
    3435127
  • 项目类别:
  • 资助金额:
    $0.2万
  • 财政年份:
    1991
  • 负责人:
    CHARLES Frederick FOX
  • 依托单位:
CONFERENCE ON IMMUNOPATHOGENESIS OF RHEUMATOID ARTHRITIS
  • 批准号:
    3433765
  • 项目类别:
  • 资助金额:
    $0.9万
  • 财政年份:
    1991
  • 负责人:
    CHARLES Frederick FOX
  • 依托单位:
海外基金