CONFERENCE ON PROTEIN FOLDING AND DESIGN

蛋白质是如何折叠成它们独特的三维结构的？如何 蛋白质的三维结构能产生功能吗？ 蛋白质是可以设计的吗，无论是从第一原理还是通过 天然蛋白质亚结构的重建可低分子量 和高度稳定的天然蛋白质的模拟物本次会议 我将描述理解这些问题的进展， 现代分子生物学的核心 近年来折叠图案 已经在多种基因调节蛋白中被识别，并且它们的 通过预测方法的组合来确定结构， 核磁共振和晶体学。 折叠问题取得重大进展 已经进行了体外研究以及整个细胞。 巨大进展 在理解膜的结构和功能方面取得了很大进展， proteins. 我们已经开始研究和操纵 使用免疫球蛋白的生物分子识别和相关的 分子。 这次会议应该把化学家，分子， 生物学家和细胞生物学家来回顾这些领域的最新进展， 并讨论这个多学科领域的未来。

How do proteins fold into their unique three-dimensional structures? How does the three dimensional structure of a protein give rise to function? Can proteins be designed, either from first principles or through reconstruction of natural protein substructures? Can low molecular weight and highly stable mimics of natural proteins be designed? This meeting will describe progress towards understanding these questions that lie at the heart of modern molecular biology. In-recent years folding motifs have been recognized in a variety of gene regulatory proteins, and their structures are being determined by a combination of predictive methods, NMR, and crystallography. Considerable progress with the folding problem has been made in vitro studies as well as whole cells. Enormous progress has been made in understanding the structures and functions of membrane proteins. We have begun to study and manipulate the repertoire of biological molecular recognition using immunoglobulins and related molecules. This meeting should bring together chemists, molecular biologists, and cellular biologists to review recent advances in these areas, and discuss the future of this multidisciplinary field.