CONFERENCE ON GROWTH FACTOR SIGNAL TRANSDUCTION

近年来，对生长因子的认识有了重大突破。 信号转导。血小板源生长的三个蛋白质靶点 具有与细胞信号转导相关的酶活性的因子受体 已发现：磷脂酶C，c-raf丝氨酸激酶和 磷脂酰肌醇-3激酶。其他蛋白酪氨酸激酶激活 这些酶的亚群。另一个令人兴奋的发展是发现 编码G蛋白相关受体的某些基因可以转化细胞 在文化上。最后，在确定角色方面取得了很大进展 小分子GTP结合蛋白(类ras)在细胞生长和转化中的作用。 主要的问题是确定什么是蜂窝信令系统 对增长反应至关重要。一个相关的、更容易接近的问题是 生长因子受体启动的生化机制 次要反应，如丝氨酸激酶的激活和刺激 磷脂酰肌醇周转率。这次会议的目标是接近 这些问题是通过将那些已经制造出关键技术的科学家聚集在一起 这些发现表明已建立的油田之间存在新的联系。例如, 关于G蛋白相关受体的会议将强调 基因具有致癌潜力的受体及其研究进展 细胞质丝氨酸激酶将侧重于生长的机制 因子受体调节丝氨酸激酶。

Recently, major breakthroughs have occured in understanding growth factor signal transduction. Three protein targets of the platelet derived growth factor receptor with enzymatic activities relevant to cell signalling have been discovered: phospholipase C, c-raf serine kinase and phosphatidylinositol-3kinase. Other protein-tyrosine kinases activate subsets of these enzymes. Another exciting development is the discovery that certain genes which encode G protein-linked receptors transform cells in culture. Finally, much progress has been made in determining the role of small GTP binding proteins (ras like) in cell growth and transfomation. The major problem is to determine what cellular signalling systems are critical for growth responses. A related, and more approachable problem is the biochemical mechanism by which growth factor receptors turn on secondary responses such as activation of serine kinases and stimulation of phosphatidylinositol turnover. The goal of the meeting is to approach these problems by bringing together those scientists who have made key discoveries suggesting new links between established fields. For example, the session on G protein-linked receptors will emphasize the subject of receptors whose genes have oncogenic potential and the session on cytoplasmic serine kinases will focus on the mechanisms by which growth factor receptors regulate serine kinases.