1989 GORDON RESEARCH CONFERENCE ON PROTEINS

为戈登研究会议的部分支持寻求资金 1989年蛋白质(GRC)，将用于支付旅行和住宿费用 面向特邀演讲者和年轻科学家的董事会。像其他GRC一样 蛋白质会议是一个小型的、独特的论坛，在这里可以获得新的结果 在非正式场合进行讨论，有助于交流思想和 合作研究计划的制定。GRC蛋白已经被 在奇数年举行的一年两次的会议。1988年的会议是 用来确定年度格式的更改是否 这是正当的。关于这一点的最终决定将在1989年的会议上做出，时间是 出席者。 近年来，有三个因素使蛋白质研究发生了革命性的变化。 克隆技术的出现加上过度繁殖技术的发展 表达载体使生物化学、细胞生物学和 迄今为止许多蛋白质的结构研究只能在很短的时间内获得 金额。定向突变的使用提供了询问和 回答比以前更详细、更集中的问题 传统上是可寻址的。X射线结晶学的改进 方法意味着更多的结构正在被确定。同舟共济 这些技术引发了蛋白质研究的复兴。这个 计划将重点放在进展特别快的领域 在理解蛋白质的生物学功能和活性方面取得了进展 它们的结构术语。 尽管该计划仍在不断变化中，但我们已经确定了 以下课程题目：-蛋白质折叠和展开的能量学，- 转运/受体：膜、通道和孔-实验探针 蛋白质动力学-工具在分子中的应用：二氢叶酸 还原酶和葡萄球菌核酸酶，-X射线结构，-进化和 结构的遗传探针(和逆序)，-多肽模型

Funds are sought for partial support of the Gordon Research Conference (GRC) on Proteins for 1989 and will be used to support travel and room and board for invited speakers and young scientists. Like other GRC's the Conference on Proteins is a small, unique forum where new results can be discussed in an informal setting conductive to the exchange of ideas and the creation of plans for collaborative research. The Proteins GRC has been a biannual conference given in odd-numbered years. The 1988 conference was an experiment to determine whether a change to an annual format was warranted. A final decision about this will be made at the 1989 meeting by the attendees. Three factors have revolutionized the study of proteins in recent years. The advent of cloning technology coupled with the development of over- expression vectors has made possible the biochemical, cell-biological and structural study of many proteins hitherto only available in minute amounts. The use of directed mutagenesis provides the ability to ask and answer much more detailed and highly focussed question than have traditionally been addressable. The improvement in x-ray crystallographic methods means that many more structures are being determined. Together these techniques have evoked a renaissance in the study of proteins. The program will emphasize areas where particularly rapid progress is being made in understanding the biological function and activity of proteins in terms of their structures. Although the program is still very much in flux, we have identified the following session titles: -Energetics of Protein Folding and Unfolding, - Transport/Receptors: membranes, channels and pores, -Experimental Probes of Protein Dynamics, -Applications of tools to molecules: dihydrofolate reductase and staphylococcal nuclease, -X-ray structures, -Evolutionary and genetic probes of Structure (and the Converse), -Peptide Models