INTERNATIONAL SYMPOSIUM ON BRAIN-GUT INTERACTIONS

这次会议的目的是促进一个跨学科的 交流脑-肠道相互作用研究的知识，并提供 对GUT感兴趣的年轻研究人员和实习生的机会 神经生物学与这一领域的专家互动。在这方面的进展 几项发现和新技术加速了大脑-肠道的形成， 也就是说，几种生物活性多肽的表征 大脑和肠道和展示了强大的中枢 神经肽在神经系统中的作用 胃肠功能，包括转运、运动和分泌。这个 辣根过氧化物酶(HRP)技术与电子结合的应用 显微镜或免疫组织化学提供了新的工具来阐明 肠道传入和传出投射与电生理技术 已经导致了脑干中胃神经元的特征。 特邀演讲者将讨论与以下主题有关的问题：(1) 包括延髓在内的脑肠相互作用的神经解剖学基础 胃肠道传入和传出通路的组织--下丘脑 与延髓和脊髓自主神经核团的联系以及神经活动 这些核团中的物质；(2)肠道的外源性神经支配， 包括支配胃肠道的纤维的特征和 迷走神经中化学物质和受体的轴突运输：(3) 脊髓和迷走神经通路对胃功能的传入调节 感觉性机械、温度和化学感受器的最新信息 肠道；(4)胃肠道分泌和运动的脑调节 多肽和神经递质的功能：(5)行为和脑-肠道 胃肠调节饱足感的相互作用 传入通路与中枢CCK释放：(6) 肠道的病理生理学，包括呕吐、内脏疼痛和 中枢神经系统相关功能障碍：及(7)应激与胃肠道改变 功能，包括临床研究和实验数据的作用 促肾上腺皮质激素释放因子(CRF) 这次会议将首次为神经解剖学家提供一个论坛， 药理学家、电生理学家、胃肠病学家和 生理学家就他们目前的研究活动进行互动，以 划定进一步发展的地区，并确定未来发展的方向 在接下来的几年里探索过。这本书将由乌鸦出版社以 会议的成果将是第一部关于 主题。

The objectives of this conference are to facilitate an interdisciplinary exchange of knowledge on brain-gut interaction research and to provide the opportunity for young investigators and trainees interested in gut neurobiology to interact with experts in this field. Progress in the brain-gut has been accelerated by several findings and new techniques, namely, the characterization of several biologically active peptides in both the brain and the gut and the demonstration of potent central nervous system-mediated actions of neuropeptides which influence gastrointestinal function including transit motility and secretion. the use of horseradish peroxidase (HRP) techniques combined with electron microscopy or immunohistochemistry has provided new tools to elucidate gut afferent and efferent projections and electrophysiologic techniques have lead to the characterization of gastric neurons in the brain stem. Invited speakers will address issues related to the following topics: (1) neuroanatomical basis of brain-gut interactions including the medullary organization of GI afferent and efferent pathways, the hypothalamic connections with medullary and spinal autonomic nuclei, and neuroactive substances in these nuclei; (2) extrinsic innervation of the gut, including characterization of the fibers innervating the GI tract and axonal transport of chemicals and receptors in the vagus nerve: (3) afferent modulation of gastric function by spinal and vagal pathways and recent information on sensory mechano-thermo-, and chemoreceptors in the gut; (4) brain regulation of gastrointestinal secretory and motor function by peptides and neurotransmitters: (5) behavior and brain-gut interactions exemplified by the modulation of satiety by gastrointestinal afferent pathways and central cholecystokinin (CCK) release: (6) pathophysiology of the intestine including vomiting, visceral pain, and CNS-related functional disorders: and (7) stress and alterations of GI function, including clinical studies and experimental data on the role of corticotropin-releasing factor (CRF). The meeting will provide for the first time a forum for neuroanatomists, pharmacologists, electrophysiologists, gastroenterologists, and physiologists to interact on their current research activities, to delineate areas for further development, and to identify directions to be explored in the coming years. The book to be published by Raven Press as a result of the meeting will be the first comprehensive monograph on the subject.