ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

昼夜体温节律的个体发生

• 批准号: 3449759
• 负责人: E M KITTRELL
• 金额: $ 4.58万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-02-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3449759
• 关键词: aging; body temperature regulation; circadian rhythms; eating; experimental brain lesion; growth /development; infant animal; lighting; mature animal; mother child interaction; neurophysiology; telemetry; temperature

The adult rat (Rattus norvegicus) has a prominent 24-hr variation in body temperative (Tb). Althrough subject to external influences, the circadinan temperature rhythm is endogenously generated and persists when environmental cues are held constant. The hypothalamus appears to be critically involved in the CTR system, but the underlying neural circuitry remains to be worked out. Very little is known regarding developmental influences on the emergence and expression of the CTR in rats. I am proposing a program of research to examine maternal, environmental, and neural contributions to the development of the CTR in rats. Continuous 10-min-interval measurements of telemetered Tb from 8 or 10 Days of age to adulthood will be used to determine period, phase, and amplitude changes in the CTR over this time period. The combupterized data collection system is currently in operation in our lab. I plan experiments which will help answer such questions as: 1) Does the dam impose a CTR on her pups that is reflected in the development of their CTR? 2) how does the CTR develop from Day 1 in pups deprived of maternal influences? 3) Do light, temperature, and feeding cycles affect CTR emergence? 4) what role do various hypothalamic areas play in CTR ontogeny? 5) Are there circadian variations in temperature regulation during development? Information regarding these issues and others is presently unavailable. It is known, however, that loss of temporal organization among biological systems characterizes the aging process in humans and animals. It has also been suggested that a serious thermoregulatory deficit observed in elderly persons, accidental hypothermia, may be a result of circadian desynchronization of thermoregulatory mechanisms in the face of thermal challenge. Our knowledge of rhythm dissociations and aging will be enhanced by a clearer understanding of the ontogenetical processes that contribute to temporal organization in developing organisms. The CTR is intimately linked with rhythmical patterns observed in other physiological systems. Light shed on CTR development will reflect on rhythm emergence in rodents in general and may illuminate maturetional processes and environmental influences critical to normal functioning.

成年大鼠（Rattusnorvegicus）的24小时身体变化显着 温带（Tb）。 尽管受外界影响，昼夜节律 温度节律是内源产生的，并且在以下情况下持续存在： 环境线索保持不变。 下丘脑似乎是 关键参与 CTR 系统，但底层神经回路 仍有待解决。 对于发育的了解甚少 对大鼠 CTR 的出现和表达的影响。 我是 提出一项研究计划来检查母亲、环境和 神经对大鼠 CTR 发展的贡献。 连续的 从 8 或 10 天龄到 成年期将用于确定周期、相位和幅度的变化 这段时间内的点击率。 燃烧式数据采集系统是 目前在我们的实验室运行。 我计划进行一些有帮助的实验 回答以下问题： 1) 母犬是否对她的幼崽施加了 CTR，即 反映在他们的点击率的发展上？ 2）点击率如何发展 从第一天起，幼崽就失去了母亲的影响？ 3）做光， 温度和喂养周期会影响 CTR 的出现吗？ 4) 扮演什么角色 下丘脑的各个区域在 CTR 个体发育中发挥作用？ 5）有昼夜节律吗 发育过程中温度调节的变化？ 信息 目前无法获得有关这些问题和其他问题的信息。 我们都知道， 然而，生物系统之间时间组织的丧失 描述了人类和动物衰老过程的特征。 也曾被 表明老年人存在严重的体温调节缺陷 人意外体温过低，可能是昼夜节律的结果 面对热时温度调节机制的不同步 挑战。 我们对节律分离和衰老的了解将是 通过对个体发生过程的更清晰的理解而得到加强 有助于发育中有机体的时间组织。 点击率是 与在其他生理学中观察到的节律模式密切相关 系统。 CTR 发展的亮点将反映在节奏的出现 一般啮齿类动物，可以阐明成熟过程和 环境影响对正常功能至关重要。