ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

昼夜体温节律的个体发生

• 批准号: 3413127
• 负责人: E M KITTRELL
• 金额: $ 5.56万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413127
• 关键词: body temperature; body temperature regulation; brain regulatory center; circadian rhythms; experimental brain lesion; gestational age; growth /development; histology; hypothalamus; immature animal; laboratory rat; lactation; neurophysiology; newborn animals; prenatal stress; prolactin; psychomotor function; stereotaxic techniques; water drinking behavior

There is a highly specific temporal ordering of rhythmic patterns in physiological systems. Sleep-wake cycles, growth-hormone secretion, potassium secretion, and cortisol levels all fluctuate in a precise relationship with the circadian temperature rhythm (CTR). The timing of these physiological processes is quite similar across numerous species. There is a growing body of evidence that loss of temporal organization among various biological rhythm systems is a concomitant of some forms of mental illness such as depression, and manic depressive illness. The mechanisms that link rhythm abberations to mood disorders are unknown, but the data currently being gathered suggest that the association of the two is more than casual. The CTR is one of the rhythm systems that appears disturbed in mood disorders. We have been engaged in studying the ontogeny of the CTR in rats and have reported that the CTR emerges around 25 days of age and continues to develop until 35-40 days. We plan to continue this work by examining behavioral, physiological, and neurophysiological mechanisms that may underlie rhythm ontogeny in the rat with a particular emphasis on the development and subsequent maintenance of the CTR. We measure temperature, drinking, and activity via telemetry signals every 5 min from 10 days of age. Studies on the ontogeny of various rhythms in rodents suggest that both prenatal and postnatal factors affect the development of normal rhythmicity. Our knowledge of rhythm dysfunction effects upon mental health disorders can be enhanced by a better understanding of the ontogenetical processes that produce temporal organization in biological organisms. Light shed on CTR development may reflect on rhythm ontogeny in general and illuminate maturational processes and environmental influences critical to normal functioning.

节奏模式有高度特定的时间顺序 在生理系统中。 睡眠-觉醒周期、生长激素 分泌、钾分泌和皮质醇水平均在 与昼夜节律的精确关系 （点击率）。 这些生理过程的发生时间相当 许多物种都相似。 有一个不断增长的身体 有证据表明，不同群体之间的时间组织丧失 生物节律系统是某些形式的伴随物 精神疾病，例如抑郁症和躁狂抑郁症。 将节律失常与情绪障碍联系起来的机制 未知，但目前收集的数据表明 两者的联系绝非偶然。 点击率是其中之一 情绪障碍时出现紊乱的节律系统。 我们一直致力于研究大鼠CTR的个体发育 并报道 CTR 在 25 日龄左右出现 并持续发育直至35-40天。 我们计划继续 这项工作通过检查行为、生理和 节律背后的神经生理机制 大鼠的个体发育，特别强调发育 以及CTR的后续维护。 我们测量 每 5 次通过遥测信号获取温度、饮酒和活动信息 分钟从 10 天龄起。 各种个体发育的研究 啮齿类动物的节律表明，产前和产后 影响正常节律发育的因素。 我们的 了解心律失常对心理健康的影响 通过更好地了解疾病可以得到改善 产生时间组织的个体发生过程 生物有机体。 CTR 发展的曙光可能 反思一般的节律个体发育并阐明成熟 对正常运行至关重要的过程和环境影响 发挥作用。