ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

节律模式有一个高度特定的时间顺序 在生理系统中。睡眠-觉醒周期，生长激素 分泌、钾分泌和皮质醇水平都在 与昼夜温度节律的精确关系 (CTR)。这些生理过程的时间相当长 在许多物种中都相似。有越来越多的 证据表明，在不同的人之间失去了时间组织 生物节律系统是某些形式的 精神疾病，如抑郁症和躁郁症。 将节奏颤抖与情绪障碍联系起来的机制 是未知的，但目前正在收集的数据表明 这两个人的联系不仅仅是偶然的。CTR是 情绪紊乱时的节律系统似乎受到了干扰。 我们一直致力于研究大鼠CTR的个体发育。 并报告说，CTR在出生后25天左右出现 并持续发育到35-40天。我们计划继续 这项工作是通过检查行为、生理和 可能构成节律基础的神经生理机制 大鼠的个体发育，特别强调发育 以及随后的CTR维护。我们测量 温度、饮酒和活动，每隔5天通过遥测信号 从10日龄起最低。不同物种个体发育的研究 啮齿动物的节律表明，出生前和出生后 影响正常节律性发展的因素。我们的 节律障碍对心理健康影响的认识 通过更好地了解 产生时间组织的个体发生过程 生物有机体。CTR发展的曙光可能 对节奏个体发生的总体反思和对成熟的启示 对正常至关重要的过程和环境影响 功能正常。

There is a highly specific temporal ordering of rhythmic patterns in physiological systems. Sleep-wake cycles, growth-hormone secretion, potassium secretion, and cortisol levels all fluctuate in a precise relationship with the circadian temperature rhythm (CTR). The timing of these physiological processes is quite similar across numerous species. There is a growing body of evidence that loss of temporal organization among various biological rhythm systems is a concomitant of some forms of mental illness such as depression, and manic depressive illness. The mechanisms that link rhythm abberations to mood disorders are unknown, but the data currently being gathered suggest that the association of the two is more than casual. The CTR is one of the rhythm systems that appears disturbed in mood disorders. We have been engaged in studying the ontogeny of the CTR in rats and have reported that the CTR emerges around 25 days of age and continues to develop until 35-40 days. We plan to continue this work by examining behavioral, physiological, and neurophysiological mechanisms that may underlie rhythm ontogeny in the rat with a particular emphasis on the development and subsequent maintenance of the CTR. We measure temperature, drinking, and activity via telemetry signals every 5 min from 10 days of age. Studies on the ontogeny of various rhythms in rodents suggest that both prenatal and postnatal factors affect the development of normal rhythmicity. Our knowledge of rhythm dysfunction effects upon mental health disorders can be enhanced by a better understanding of the ontogenetical processes that produce temporal organization in biological organisms. Light shed on CTR development may reflect on rhythm ontogeny in general and illuminate maturational processes and environmental influences critical to normal functioning.