ONTOGENY OF THE CIRCADIAN BODY TEMPERATURE RHYTHM

昼夜体温节律的个体发生

• 批准号: 3413126
• 负责人: E M KITTRELL
• 金额: $ 5.26万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413126
• 关键词: body temperature; body temperature regulation; brain regulatory center; circadian rhythms; experimental brain lesion; gestational age; growth /development; histology; hypothalamus; immature animal; laboratory rat; lactation; neurophysiology; newborn animals; prenatal stress; prolactin; psychomotor function; stereotaxic techniques; water drinking behavior

There is a highly specific temporal ordering of rhythmic patterns in physiological systems. Sleep-wake cycles, growth-hormone secretion, potassium secretion, and cortisol levels all fluctuate in a precise relationship with the circadian temperature rhythm (CTR). The timing of these physiological processes is quite similar across numerous species. There is a growing body of evidence that loss of temporal organization among various biological rhythm systems is a concomitant of some forms of mental illness such as depression, and manic depressive illness. The mechanisms that link rhythm abberations to mood disorders are unknown, but the data currently being gathered suggest that the association of the two is more than casual. The CTR is one of the rhythm systems that appears disturbed in mood disorders. We have been engaged in studying the ontogeny of the CTR in rats and have reported that the CTR emerges around 25 days of age and continues to develop until 35-40 days. We plan to continue this work by examining behavioral, physiological, and neurophysiological mechanisms that may underlie rhythm ontogeny in the rat with a particular emphasis on the development and subsequent maintenance of the CTR. We measure temperature, drinking, and activity via telemetry signals every 5 min from 10 days of age. Studies on the ontogeny of various rhythms in rodents suggest that both prenatal and postnatal factors affect the development of normal rhythmicity. Our knowledge of rhythm dysfunction effects upon mental health disorders can be enhanced by a better understanding of the ontogenetical processes that produce temporal organization in biological organisms. Light shed on CTR development may reflect on rhythm ontogeny in general and illuminate maturational processes and environmental influences critical to normal functioning.

有一个高度特定的节奏模式的时间顺序 在生理系统中。 睡眠-觉醒周期，生长激素 钾分泌和皮质醇水平都在波动， 与昼夜温度节律的精确关系 （CTR）。 这些生理过程的时间是相当 在许多物种中相似。 有越来越多的 有证据表明，在不同的时间组织之间的损失 生物节律系统是伴随着某些形式的 精神疾病，如抑郁症和躁狂抑郁症。 节律失常与情绪障碍的联系机制 是未知的，但目前正在收集的数据表明， 两者之间的联系并非偶然。 CTR是 在情绪障碍中出现紊乱的节律系统。 我们一直致力于研究大鼠CTR的个体发生 并报道称CTR在25天左右出现 并持续发育至35-40天。 我们计划继续 这项工作通过检查行为，生理， 神经生理学机制可能是节律的基础 大鼠的个体发育，特别强调 以及CTR的后续维护。 我们测量 通过遥测信号，每5分钟测量一次体温、饮水和活动情况。 从10日龄开始。 不同种类的个体发育研究 啮齿类动物的节律表明，产前和产后 影响正常节律性发展的因素。 我们 了解节律紊乱对心理健康的影响 疾病可以通过更好地了解 产生时间组织的个体发生过程 生物有机体 CTR开发的亮点可能 反思节奏个体发育一般和阐明成熟 对正常生产至关重要的过程和环境影响 功能