BONE INGROWTH/REMODELING IN CEMENTLESS KNEE ARTHROPLASTY

非骨水泥膝关节置换术中的骨长入/重塑

• 批准号: 3457219
• 负责人: D Rick Sumner
• 金额: $ 11.63万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3457219
• 关键词: arthrodesis; arthroplasty; biomaterial interface interaction; bone development; dogs; hip prosthesis; knee; physiologic bone resorption

Fixation of orthopedic implants by bone ingrowth into porous surfaces is being investigated as an alternative to acrylic cement in total hip and knee arthroplasty. The long-term objectives of this project are to address three key issues in the use of metallic porous coatings for the tibial component in total knee arthroplasty: (1) the relationship between initial rigid body and tangential interface displacements and tissue ingrowth, (2) the mechanical correlates of the histology of the bone-implant interface and (3) long-term aspects of bone remodeling related to cementless total knee replacement. A total knee replacement model will be used in which the method of adjuvant fixation will be altered in order to vary the initial rigid body stability and pattern of tangential interface displacements. In the first of three experiments, physical measurements of the initial displacements will be correlated with histologic findings 1,6 and 24 months after surgery. In the second experiment, physical measurements of the interface displacements will be made after a six month period of implantation and correlated with the histology of the interface. In the third experiment, changes in the architecture and remodeling dynamics of the proximal tibia will be investigated as a function of the nature of the bone-implant interface at 1, 6 and 24 months. These experiments will (1) facilitate definition of the maximum amount of relative bone-implant micromotion compatible with bone ingrowth, (2) address the question of how much bone ingrowth is needed to ensure component stability and (3) determine how variation in the nature of the bone-implant interface affects bone remodeling in the proximal tibia.

通过骨长入多孔内固定骨科植入物 表面作为丙烯酸水泥的替代品正在研究中 全髋关节和膝关节置换术。 的长期目标 该项目旨在解决金属材料使用中的三个关键问题， 用于全膝关节胫骨部件的多孔涂层 关节成形术：（1）初始刚体与 切向界面位移和组织向内生长，（2） 骨植入物组织学的机械相关性 界面和（3）骨重建的长期方面， 非骨水泥型全膝关节置换术。 将使用全膝关节置换模型，其中， 将改变辅助固定，以改变最初的 刚体稳定性与切向界面型式 流离失所。 在三个实验中的第一个，物理 初始位移的测量值将与 术后1、6、24个月组织学检查。 在第二 实验，界面位移的物理测量 将在植入六个月后进行， 与界面的组织学相关。 第三 实验，在建筑和重塑动力的变化， 将研究胫骨近端作为性质的函数 在1、6和24个月时骨-种植体界面的变化。 这些实验将（1）促进最大值的定义 与骨相容的相对骨-植入物微动量 （2）解决骨向内生长的问题， 确保组件稳定性和（3）确定如何 骨-植入物界面性质的变化影响骨 胫骨近端的重塑